Preparation, characterization and properties of quercetin cyclodextrin nanosponges

IF 2.3 4区化学 Q2 Agricultural and Biological Sciences

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2024-10-22 DOI:10.1007/s10847-024-01263-z

Wanping Zhang, Houchen Gai, Qianjie Zhang, Dongmei Zhang, Shilian Zheng, Guangyong Zhu

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引用次数: 0

Abstract

Quercetin (QC) has various biological activities such as anti-inflammatory and antibacterial properties. However, due to its poor solubility and stability, the application of QC in clinical practice is limited. Nanosponge (NS), as a new drug carrier, can significantly improve the solubility of low-soluble drug components, and significantly improve the efficacy and bioavailability of drugs. In this paper, cyclodextrin nanosponges (CDNS) were synthesized by cross-linking β-cyclodextrin with diphenyl carbonate (DPC) in a green and safe synthetic pathway. As wall material, CDNS were further used to encapsulate quercetin and quercetin-cyclodextrin nanosponges (QCNS) were formed. The resultant CDNS and QCNS were characterized by scanning electron microscopy, infrared spectroscopy, X-ray diffraction, and thermogravimetric analysis. The results showed that CDNS and QCNS were successful prepared. The solubilizing impact of CDNS on quercetin was investigated. The results showed that its solubility in water was 176 times higher than that of pure QC. The cumulative release of quercetin and QCNS over 48 h and the cumulative transdermal penetration over 12 h were measured. The antioxidant and antibacterial properties of QCNS were determined. QCNS exhibited superior stability, permeability, and sustained-release properties compared to pure quercetin, and had notable bacteriostatic and antioxidant capabilities.

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry 化学-化学综合

CiteScore

3.30

自引率

8.70%

发文量

审稿时长

3-8 weeks

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.