Natural products targeting ubiquitination to combat kidney fibrosis

IF 3.4 Q2 PHARMACOLOGY & PHARMACY
Lianhua Li, Xinhui Huang, Yao Chen, Jibin Liu, Yuhang Qiao, Wenyu Fan, Peiqing Zhang, Xiaoming Yan, Ming Chen
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引用次数: 0

Abstract

Background

Kidney fibrosis is a crucial component that contributes to end-stage renal disease and is the inevitable last pathological process in many progressive chronic kidney diseases (CKD). Ubiquitination, one of the most refined and widespread reversible post-translational modifications, plays a significant role in the development of renal fibrosis through its regulation and deubiquitination processes.

Main body of the abstract

Recent studies have shown that ubiquitination and deubiquitination represent promising intervention targets against renal fibrosis, with numerous natural products intervening in renal fibrosis by regulating the processes of ubiquitination and signal pathways such as transforming growth factor-β1/Smads (TGF-β1/Smads), Wnt/β-catenin, Janus kinase/signal transducer and activator of transcription/suppressor of cytokine signaling (JAK/STAT/SCOS), and nuclear factor erythroid-derived 2-like 2 (Nrf2), and then link.

Conclusion

Herein, we summarize the processes of ubiquitination and deubiquitination and introduce the interactions between ubiquitination and natural products. This is conducive to the development of new candidate drugs that intervene in renal fibrosis through the regulation of ubiquitination, representing a promising strategy to combat renal fibrosis with natural products.

Graphical abstract

针对泛素化的天然产物对抗肾纤维化
肾纤维化是导致终末期肾脏疾病的重要因素,也是许多进行性慢性肾脏疾病(CKD)不可避免的最后病理过程。泛素化是最精细和最广泛的可逆翻译后修饰之一,通过其调控和去泛素化过程在肾纤维化的发展中起着重要作用。近年来的研究表明,泛素化和去泛素化是很有希望干预肾纤维化的靶点,许多天然产物通过调节泛素化过程和信号通路,如转化生长因子-β1/Smads (TGF-β1/Smads)、Wnt/β-catenin、Janus激酶/信号转导器和转录激活因子/细胞因子信号抑制因子(JAK/STAT/SCOS)、和核因子红细胞衍生2样2 (Nrf2),然后连接。结论综述了植物的泛素化和去泛素化过程,并介绍了泛素化与天然产物的相互作用。这有利于开发通过调控泛素化干预肾纤维化的新候选药物,代表了一种利用天然产物对抗肾纤维化的有希望的策略。图形抽象
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来源期刊
自引率
0.00%
发文量
44
审稿时长
23 weeks
期刊介绍: Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.
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