Study of the Inhibition of Schumann Resonance-inspired Electromagnetic Field on Cancer Cell Proliferation

IF 4.9 3区计算机科学 Q1 ENGINEERING, MULTIDISCIPLINARY

Journal of Bionic Engineering Pub Date : 2024-12-17 DOI:10.1007/s42235-024-00624-1

Xianqiang Yan, Xuelei Liu, Shujun Zhang, Zhenning Liu, Luquan Ren

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Abstract

Organisms on Earth evolve and coexist with natural Electromagnetic Fields (EMFs). Although many reports have suggested the potential anti-neoplastic effects of EMFs with specific parameters, the studies on the influence of natural EMFs on cancers are still rare. Herein, an EMF emitter has been developed to investigate the effects of the extremely-low frequency SR-mimicking EMF (SREMF) on cancer and normal cell proliferation. The numerical simulation has revealed that the emitter with specific parameters is able to enhance EMF intensity and uniformity on the designated plane above the emitter. More importantly, honeycomb-like emitter array can generate a stronger EMF intensity on the 20 mm plane above the array. Cell colony formation assays have demonstrated that SREMF generated by the honeycomb-like emitter array can significantly inhibit Hela cell proliferation in a cell-density-dependent manner. The morphological changes of SREMF-exposed Hela cells suggest that the anti-proliferative effect of SREMF may be caused by apoptosis induction. In contrast, no detrimental effect is observed for SREMF-treated normal cells, which probably can be explained by the evolutionary adaptation. Hence, this work can not only contribute to understanding the impact of natural EMF on creatures, but also afford a novel strategy to personalized cancer prevention and treatment.

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来源期刊

Journal of Bionic Engineering 工程技术-材料科学：生物材料

CiteScore

7.10

自引率

10.00%

发文量

162

审稿时长

10.0 months

期刊介绍： The Journal of Bionic Engineering (JBE) is a peer-reviewed journal that publishes original research papers and reviews that apply the knowledge learned from nature and biological systems to solve concrete engineering problems. The topics that JBE covers include but are not limited to: Mechanisms, kinematical mechanics and control of animal locomotion, development of mobile robots with walking (running and crawling), swimming or flying abilities inspired by animal locomotion. Structures, morphologies, composition and physical properties of natural and biomaterials; fabrication of new materials mimicking the properties and functions of natural and biomaterials. Biomedical materials, artificial organs and tissue engineering for medical applications; rehabilitation equipment and devices. Development of bioinspired computation methods and artificial intelligence for engineering applications.