{"title":"Synthesis of dual-responsive carboxymethyl cellulose–based nanogels for drug delivery applications","authors":"Yuanpeng Cai, Danyang Li, Shaohua Peng, Hui Liu","doi":"10.1007/s00396-024-05350-y","DOIUrl":null,"url":null,"abstract":"<div><p>Nanogels offered a large surface area for biological conjugation due to their nanoscale size, enabling prolonged circulation in the bloodstream and targeted delivery to specific tissues. CMC/POM nanogels composed of 2-(2-(2-methoxyethoxy)ethoxy)ethyl methacrylate (MEO<sub>3</sub>MA), methacrylic acid (MAA), and natural biopolymer carboxymethyl cellulose (CMC) were synthesized via free radical polymerization. The chemical structures of CMC/POM nanogels were characterized using several techniques, and the responsive behaviors under temperature and pH variations were reflected by changes in turbidity and particle size. The results demonstrated that CMC/POM nanogels exhibited significant changes in particle size and turbidity around 38 °C and under different pH conditions. Additionally, the unique microstructure of CMC/POM nanogels made them promising for drug delivery through injection therapy. With doxorubicin (DOX) as a model drug, the nanogels could achieve a maximum drug loading content of 31.47% and drug loading efficiency of 62.93%. During in vitro controlled drug releasing, the release efficiency was up to 92.20% within 24 h at <i>T</i> = 45 °C and pH = 3.0. The cytotoxicity assays confirmed that CMC/POM nanogels possessed superior biocompatibility and drug-loaded CMC/POM nanogels effectively inhibited the activity of cancer cells. CMC/POM nanogels displayed remarkable potential as intelligent drug delivery systems, and they were expected to play an essential role in the field of anticancer therapies.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"303 2","pages":"287 - 300"},"PeriodicalIF":2.2000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid and Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s00396-024-05350-y","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Nanogels offered a large surface area for biological conjugation due to their nanoscale size, enabling prolonged circulation in the bloodstream and targeted delivery to specific tissues. CMC/POM nanogels composed of 2-(2-(2-methoxyethoxy)ethoxy)ethyl methacrylate (MEO3MA), methacrylic acid (MAA), and natural biopolymer carboxymethyl cellulose (CMC) were synthesized via free radical polymerization. The chemical structures of CMC/POM nanogels were characterized using several techniques, and the responsive behaviors under temperature and pH variations were reflected by changes in turbidity and particle size. The results demonstrated that CMC/POM nanogels exhibited significant changes in particle size and turbidity around 38 °C and under different pH conditions. Additionally, the unique microstructure of CMC/POM nanogels made them promising for drug delivery through injection therapy. With doxorubicin (DOX) as a model drug, the nanogels could achieve a maximum drug loading content of 31.47% and drug loading efficiency of 62.93%. During in vitro controlled drug releasing, the release efficiency was up to 92.20% within 24 h at T = 45 °C and pH = 3.0. The cytotoxicity assays confirmed that CMC/POM nanogels possessed superior biocompatibility and drug-loaded CMC/POM nanogels effectively inhibited the activity of cancer cells. CMC/POM nanogels displayed remarkable potential as intelligent drug delivery systems, and they were expected to play an essential role in the field of anticancer therapies.
期刊介绍：
Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.
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