Evaluation of radiochemical yield and quality in automated [18F]fluorocholine synthesis with a modified GE TracerLab MX module

IF 1.5 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2024-11-01 DOI:10.1007/s10967-024-09846-3

Md. Jashim Uddin, Yun-Sang Lee, Yong-Hyun Cho, M. Anwar-Ul-Azim, Salma Khanom

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Abstract

[¹⁸F]fluorocholine ([¹⁸F]FCH) is an effective tracer for the imaging of different tumors of human brain, lung, or prostate. The purpose of this study was to evaluate the radiochemical yield and quality of routinely synthesized [¹⁸F]FCH by a modified 2-deoxy-2-[¹⁸F]fluoro-d-glucose ([¹⁸F]FDG) synthesizer (GE TracerLab MX). The radiosynthesis of [¹⁸F]FCH was completed in two steps taking 49 min. First, [¹⁸F]fluorobromomethane ([¹⁸F]FCH₂Br) was synthesized from [¹⁸F]fluoride and dibromethane. Then, [¹⁸F]FCH as bromide salt was produced by N-alkylation of N,N-dimethylaminoethanol (DMAE) with [¹⁸F]fluorobromomethane. [¹⁸F]FCH had > 99.99% radiochemical purity, with non-decay-corrected and decay-corrected yields of 12(± 3)% and 16(± 4)%, respectively (n = 8).

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.