Bone cement prepared using the isobornyl acrylate monomer shows decent mechanical strength and antibacterial activity

Abstract

A new type of antibacterial bone cement incorporating surface stereochemistry and the antibacterial monomer isobornyl acrylate (BA) is reported. In this study, BA was integrated into poly(methyl methacrylate) (PMMA) bone cement through liquid-phase modification to create a non-leaching antibacterial bone cement (NLBC). The maximum temperature, setting time, antibacterial activity, mechanical strength, and biocompatibility of this NLBC were comprehensively evaluated. The results showed that the BA cement exhibited exceptional antibacterial activity and mechanical properties. The 30 wt% BA cement demonstrated an antibacterial activity of 81.0 ± 3.1% against Staphylococcus aureus and a compressive strength of 72.10 ± 1.97 MPa. The BA cement exhibited good biocompatibility both in vitro and in vivo. Furthermore, we compared the antibacterial activity, mechanical properties, and biocompatibility of the BA cement with those of three previously reported bone cements, which contain the antibacterial monomers 2-(tert-butylamino)ethyl methacrylate (TBAEMA), methacrylate derived from benzothiazole (BTTMA), and nitrofuran methacrylate (NFMA), respectively. The findings of this study have important implications for the advancement of antibacterial bone cement and its application in medical implants.