High prevalence and non-suppression of HIV/AIDS in the East and Central African region heightens risk of severe outcomes for Clade I monkeypox virus infection, and may be a driver for subsequent adaptation

Henry Kyobe Bosa , Winters Muttamba , Barnabas Bakamutumaho , Edson Rwagasore , John Runumu , Mudarshiru Bbuye , Wilber Sabiiti , Abdul Nyanzi , Jacqueline Weyer , Joel Francis , Ntuli A. Kapologwe , Patrick Katoto , Bruce Kirenga , Misaki Wayengera
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Abstract

In September 2023, a re-emergence of mpox was noted in the province of South Kivu, in DR Congo. So far, active transmission has been reported in 23 of the 26 provinces. Despite localisation within DRC, there are emerging concerns about possibility of cross-border transmission. In this perspective, we highlight the threat posed to HIV positive patients, particularly those with unsuppressed viral loads. We make several prepositions as part of the preparedness and response plans in the countries in the East and Central Africa region. The six prepositions include: 1) operationalize the Joint Africa Task Force for mpox consistent with Kinshasa declaration on mpox, 2) increased surveillance, 3) deployment of point of care diagnostics, 4) targeted reactive vaccination and enhanced antiretroviral therapy of HIV positive patients in areas of active transmission, 5) community engagement, 6) foster capacity building of national rapid response teams in East and Central Africa in mpox care and management through collaboration with DRC counterparts.
在东非和中非地区,艾滋病毒/艾滋病的高流行率和未得到抑制增加了I支猴痘病毒感染严重后果的风险,并可能成为随后适应的驱动因素
2023年9月,刚果民主共和国南基伍省注意到麻疹再次出现。到目前为止,在26个省中的23个省报告了活跃传播。尽管在刚果民主共和国境内存在本地化,但人们对跨境传播的可能性日益感到担忧。从这个角度来看,我们强调对HIV阳性患者构成的威胁,特别是那些未抑制病毒载量的患者。作为东非和中非区域各国防范和应对计划的一部分,我们提出了几个介词。这六个介词包括:1)根据金沙萨关于mpox的宣言建立非洲联合mpox工作队,2)加强监测,3)部署护理点诊断,4)在活跃传播地区有针对性的反应性疫苗接种和加强对艾滋病毒阳性患者的抗逆转录病毒治疗,5)社区参与,6)通过与刚果民主共和国同行合作,促进东非和中非国家快速反应小组在mpox护理和管理方面的能力建设。
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