Mucoadhesive gellan gum/poly(2-ethyl-2-oxazoline) films for ocular delivery of pilocarpine hydrochloride

IF 4.5 3区医学 Q1 PHARMACOLOGY & PHARMACY

Journal of Drug Delivery Science and Technology Pub Date : 2025-02-01 DOI:10.1016/j.jddst.2024.106492

Guzel K. Abilova , Shamil F. Nasibullin , Kuanysh Ilyassov , Aslan N. Adilov , Marzhan K. Akhmetova , Rouslan I. Moustafine , Yesset T. Muratov , Sarkyt E. Kudaibergenov , Vitaliy V. Khutoryanskiy

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Abstract

The study aims to develop new prolonged delivery systems of pilocarpine hydrochloride (pilocarpine⸱HCl) for the therapy of glaucoma. Polymer films based on gellan gum (GG) and its mixtures with poly(2-ethyl-2-oxazoline) (POZ) at different ratios were prepared by casting. The films were found to be homogeneous, transparent, and sufficiently flexible. The GG:POZ mixtures were examined using spectroscopic, thermal and microscopic methods. Additionally, the mechanical and mucoadhesive properties of GG and GG:POZ films were studied. It was found that the greater content of gellan gum in the mixture enhances the mechanical strength and mucoadhesive properties of GG:POZ films. In vivo experiments in rabbits were conducted to evaluate the practical application of these films loaded with pilocarpine hydrochloride. The results demonstrate the effectiveness of the polymeric films compared to traditional eye drops in terms of prolonged release of the miotic drug and extended therapeutic effect duration.

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来源期刊

Journal of Drug Delivery Science and Technology 医学-药学

CiteScore

8.00

自引率

8.00%

发文量

879

审稿时长

94 days

期刊介绍： The Journal of Drug Delivery Science and Technology is an international journal devoted to drug delivery and pharmaceutical technology. The journal covers all innovative aspects of all pharmaceutical dosage forms and the most advanced research on controlled release, bioavailability and drug absorption, nanomedicines, gene delivery, tissue engineering, etc. Hot topics, related to manufacturing processes and quality control, are also welcomed.