L-shaped relationship of Vitamin D and blood lead levels among preschool children age 3–6: A cross-sectional study

IF 2.3 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Clinical Epidemiology and Global Health Pub Date : 2025-01-01 DOI:10.1016/j.cegh.2024.101864

Shengying Zhang, Bibo Mao, Fei Xu, Chenbo Zhou, Wenyuan Liu

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引用次数: 0

Abstract

Background

Childhood lead exposure negatively impacts health, and its link to Vitamin D levels in preschoolers is not well understood.

Objective

To investigate the association between Vitamin D and blood lead levels (BLLs) in Chinese preschool children aged 3-6.

Methods

A cross-sectional study of 604 children from three Ningbo kindergartens in 2019 measured serum Vitamin D using Chemiluminescence Immunoassay and BLLs via ICP-MS. We used multivariate linear regression, adjusting for factors like age, gender, BMI, hemoglobin, family income, parental occupations, and residential location, and smooth curve fitting to analyze the dose-response relationship.

Results

The average age was 5.4 ± 0.8 years, with BLLs at 19.7 ± 12.1 µg/L. Each 1 ng/mL increase in Vitamin D correlated with a 0.29 µg/L decrease in BLLs (95% CI: -0.43 to -0.16, p < 0.001). The inverse association was significant in males and suburban residents. A threshold effect was identified at 38.679 ng/mL Vitamin D, beyond which BLLs did not decrease further (β = -0.506, 95% CI: -0.777 to -0.235, p <0.001).

Conclusions

Higher Vitamin D levels are significantly linked to lower BLLs, especially in males and suburban residents, with a threshold at 38.679 ng/mL. Above this, no further BLL reduction is observed, highlighting the importance of optimal Vitamin D levels in mitigating lead exposure.

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来源期刊

Clinical Epidemiology and Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

4.60

自引率

7.70%

发文量

218

审稿时长

66 days

期刊介绍： Clinical Epidemiology and Global Health (CEGH) is a multidisciplinary journal and it is published four times (March, June, September, December) a year. The mandate of CEGH is to promote articles on clinical epidemiology with focus on developing countries in the context of global health. We also accept articles from other countries. It publishes original research work across all disciplines of medicine and allied sciences, related to clinical epidemiology and global health. The journal publishes Original articles, Review articles, Evidence Summaries, Letters to the Editor. All articles published in CEGH are peer-reviewed and published online for immediate access and citation.