Simulation analysis the impact of heat exchange structure on mixing time in fermenter

IF 3.7 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biochemical Engineering Journal Pub Date : 2025-01-10 DOI:10.1016/j.bej.2025.109635

Can Zi , Huajie Liu , Jiangwei He , Xiuhu Dang , Xiaobang Liu , Jianchang Li

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Abstract

A combination of computational fluid dynamics (CFD) and population balance model (PBM) was used to study gas-liquid mixing in a fermenter. Numerical simulations assessed how heat exchange structure and tracer injection location affect mixing time. Results show that global mixing time is mainly influenced by the flow field, especially overall circulation strength in the core region. For the upper tracer injection point, global mixing time in Models 1–4 decreases as overall circulation improves with increased spacing of heat exchange tube bundles. Improper heat exchanger structures can increase global mixing time by up to 60 %. The effect of heat exchange structures on local mixing time at the upper injection point is similar to that on global mixing time. However, local mixing time is nearly 40 % shorter, making it unsuitable for reflecting the mixing performance in large-scale fermenters. The tracer injection location significantly affects mixing efficiency, with Model 1 showing an 18 % decrease at lower injection point, while Models 2–4 experience a 7∼14 % increase. This research offers valuable insights for designing and optimizing fermenters.

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仿真分析了发酵罐换热结构对混合时间的影响

采用计算流体力学（CFD）和种群平衡模型（PBM）相结合的方法对发酵罐内气液混合进行了研究。数值模拟评估了热交换结构和示踪剂注入位置对混合时间的影响。结果表明，整体混合时间主要受流场的影响，尤其是核心区的总环流强度。对于上示踪剂注入点，随着换热管束间距的增大，模型1-4的整体混合时间随着总循环的改善而减小。不当的换热器结构可以增加整体混合时间高达60% %。换热结构对上注射点局部混合时间的影响与对整体混合时间的影响相似。但局部混合时间缩短了近40% %，不适合反映大型发酵罐的混合性能。示踪剂注入位置显著影响混合效率，模型1显示在较低的注入点降低18 %，而模型2-4则增加7 ~ 14 %。该研究为设计和优化发酵罐提供了有价值的见解。

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来源期刊

Biochemical Engineering Journal 工程技术-工程：化工

CiteScore

7.10

自引率

5.10%

发文量

380

审稿时长

34 days

期刊介绍： The Biochemical Engineering Journal aims to promote progress in the crucial chemical engineering aspects of the development of biological processes associated with everything from raw materials preparation to product recovery relevant to industries as diverse as medical/healthcare, industrial biotechnology, and environmental biotechnology. The Journal welcomes full length original research papers, short communications, and review papers* in the following research fields: Biocatalysis (enzyme or microbial) and biotransformations, including immobilized biocatalyst preparation and kinetics Biosensors and Biodevices including biofabrication and novel fuel cell development Bioseparations including scale-up and protein refolding/renaturation Environmental Bioengineering including bioconversion, bioremediation, and microbial fuel cells Bioreactor Systems including characterization, optimization and scale-up Bioresources and Biorefinery Engineering including biomass conversion, biofuels, bioenergy, and optimization Industrial Biotechnology including specialty chemicals, platform chemicals and neutraceuticals Biomaterials and Tissue Engineering including bioartificial organs, cell encapsulation, and controlled release Cell Culture Engineering (plant, animal or insect cells) including viral vectors, monoclonal antibodies, recombinant proteins, vaccines, and secondary metabolites Cell Therapies and Stem Cells including pluripotent, mesenchymal and hematopoietic stem cells; immunotherapies; tissue-specific differentiation; and cryopreservation Metabolic Engineering, Systems and Synthetic Biology including OMICS, bioinformatics, in silico biology, and metabolic flux analysis Protein Engineering including enzyme engineering and directed evolution.