Recent advances in Tetraphenylethylene-based aggregation-induced electrochemiluminescence for biosensing applications

IF 7.9 2区化学 Q1 CHEMISTRY, PHYSICAL

Current Opinion in Electrochemistry Pub Date : 2025-02-01 DOI:10.1016/j.coelec.2024.101627

Zhiyong Dong , Fangxin Du , Wei Zhang , Yu Tian , Guobao Xu

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Abstract

Tetraphenylethylene (TPE), a prominent aggregation-induced emission (AIE) emitter, has gained significant attention in the development of electrochemiluminescence (ECL) biosensors due to its unique luminescent properties. The combination of AIE and ECL improves the ECL intensity and efficiency, making TPE-based systems ideal for high-sensitivity AIECL biosensing applications. This review discusses recent advances in TPE and its derivatives based small molecular materials (e.g., nanoaggregates, organic dots, silica and vesicles confined TPE-based materials) and polymers (e.g., polymer dots, metal–organic frameworks and covalent organic frameworks) for biological applications. The AIECL principles of TPE-based materials are explored, which are mainly through molecular aggregation, spatial confinement and rigid structure to restrict the motions of TPE and reduce non-radiative transitions to realize high ECL emission. Finally, current challenges are addressed, along with perspectives on future directions to improve the performance and expand the applicability of TPE-based AIECL platforms in bioanalysis.

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来源期刊

Current Opinion in Electrochemistry Chemistry-Analytical Chemistry

CiteScore

14.00

自引率

5.90%

发文量

272

审稿时长

73 days

期刊介绍： The development of the Current Opinion journals stemmed from the acknowledgment of the growing challenge for specialists to stay abreast of the expanding volume of information within their field. In Current Opinion in Electrochemistry, they help the reader by providing in a systematic manner: 1.The views of experts on current advances in electrochemistry in a clear and readable form. 2.Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications. In the realm of electrochemistry, the subject is divided into 12 themed sections, with each section undergoing an annual review cycle: • Bioelectrochemistry • Electrocatalysis • Electrochemical Materials and Engineering • Energy Storage: Batteries and Supercapacitors • Energy Transformation • Environmental Electrochemistry • Fundamental & Theoretical Electrochemistry • Innovative Methods in Electrochemistry • Organic & Molecular Electrochemistry • Physical & Nano-Electrochemistry • Sensors & Bio-sensors •