Construction of isoindolin-1-ones via tandem reaction of ester-functionalized aziridines with amines

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-01-02 DOI:10.1080/00397911.2024.2429005

Fangfang Jing , Zhengyu Liu , Lvrong Jin , Yuhao Pang , Bo Pang , Siyang Xing , Bolin Zhu

引用次数: 0

Abstract

We have developed a tandem reaction of ester-functionalized aziridines with secondary amines for the construction of isoindolin-1-ones. Its mechanism involves sequential ring opening of aziridines and lactamization. The novel features of this tandem reaction include high efficiency, broad substrate scope and mild conditions.

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酯功能化叠氮醚与胺的串联反应构建异吲哚啉-1- 1

我们开发了酯功能化的叠氮嘧啶与仲胺的串联反应，以构建异吲哚-1- 1。其机理包括叠氮嘧啶连续开环和内酰胺化。该反应具有效率高、底物范围广、反应条件温和等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.