Spectre potentiel d'activité des nouveaux vaccins contre le pneumocoque

Q4 Medicine
R. Cohen , C. Levy , E. Varon
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引用次数: 0

Abstract

The implementation of pneumococcal conjugate vaccines (PCV7 and PCV13) in children has led to a dramatic reduction in vaccine-type pneumococcal infections, with additional benefits for adults through herd immunity. However, serotypes 3, 19A, and 19F persist at low levels in children, and new non-vaccine serotypes (NVTs) now predominate in IPD. Among the new pneumococcal vaccines approved in Europe, PCV20 covers more than 40% of invasive isolates, compared to less than 10% for PCV15. Some NVTs like 24F, not included in PCV20, remain problematic. The choice of future vaccines will depend on their ability to cover these replacement serotypes.
©2024 The Author(s). Published by Elsevier Masson SAS.
新肺炎球菌疫苗的潜在效力
在儿童中实施肺炎球菌结合疫苗(PCV7和PCV13)已导致疫苗型肺炎球菌感染的急剧减少,并通过群体免疫对成人产生额外益处。然而,血清型3、19A和19F在儿童中的水平仍然很低,而新的非疫苗血清型(NVTs)现在在IPD中占主导地位。在欧洲批准的新型肺炎球菌疫苗中,PCV20覆盖了40%以上的侵袭性分离株,而PCV15覆盖不到10%。一些nvt,如24F,不包括在PCV20中,仍然存在问题。未来疫苗的选择将取决于它们覆盖这些替代血清型的能力。©2024作者。Elsevier Masson SAS出版。
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来源期刊
Journal de Pediatrie et de Puericulture
Journal de Pediatrie et de Puericulture Medicine-Pediatrics, Perinatology and Child Health
CiteScore
0.10
自引率
0.00%
发文量
53
期刊介绍: Les articles du Journal de pédiatrie et de puériculture traitent en profondeur tous les aspects des soins à enfant dont la diversité est à image de ces professions aux rôles multiples. Les sujets traités couvrent le traitement et les soins aux enfants malades, le conseil génétique, ainsi que les techniques de pointe : nouvelles approches du diagnostic prénatal, génie génétique, etc. Les disciplines concernées sont nombreuses : pédiatrie générale, médecine fœtale et néonatale, nutrition, dermatologie, pharmacologie, psychiatrie et psychologie, puériculture pratique, enfant et société, nouvelles des congrès.
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