Targeted, pH-responsive quercetin delivery via hyaluronic acid-functionalized mesoporous nanoparticles for cancer treatment

IF 4.9 2区化学 Q2 CHEMISTRY, PHYSICAL

Colloids and Surfaces A: Physicochemical and Engineering Aspects Pub Date : 2024-12-05 DOI:10.1016/j.colsurfa.2024.135914

Hanh-Vy Tran Nguyen , Ngoc Xuan Dat Mai , Hoa Thi Lai , Linh Ho Thuy Nguyen , Quyen Toan Pham , Ha Van Nguyen , Minh-Tri Le , Thi-Hiep Nguyen , Long Binh Vong , Tan Le Hoang Doan

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Abstract

In this study, biodegradable organosilica nanoparticles were functionalized with hyaluronic acid (HA) to develop a targeted, pH-responsive drug delivery system for quercetin (QT). The QT loading capacity of the synthesized nanoparticles was assessed with varying initial QT concentrations and solvents. In vitro release profiles indicated that HA-modified nanoparticles effectively minimize QT leakage at pH 7.4, reducing premature QT loss during delivery. Cellular uptake and cytotoxicity assays demonstrated that HA-modified nanoparticles enhance cancer cell uptake by twofold compared to unmodified nanoparticles, leading to increased cytotoxicity in MCF-7 cancer cells while exhibiting no toxicity to normal L929 cells. This study highlights the potential of HA-functionalized BPMO nanoparticles for targeted cancer therapy.

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来源期刊

Colloids and Surfaces A: Physicochemical and Engineering Aspects 化学-物理化学

CiteScore

8.70

自引率

9.60%

发文量

2421

审稿时长

56 days

期刊介绍： Colloids and Surfaces A: Physicochemical and Engineering Aspects is an international journal devoted to the science underlying applications of colloids and interfacial phenomena. The journal aims at publishing high quality research papers featuring new materials or new insights into the role of colloid and interface science in (for example) food, energy, minerals processing, pharmaceuticals or the environment.