A new seco-nortriterpene and other phytochemicals from Potentilla kleiniana and their chemotaxonomic significance

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Systematics and Ecology Pub Date : 2025-01-21 DOI:10.1016/j.bse.2025.104969

Bao Zhang , Wen-Shuang Tang , Qian-Qian Jin , Li Jiang , Jia Liu , Yan-Ying Zhang , Xue Ma , Yong-Jun Li , Yue Li

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引用次数: 0

Abstract

The chemical investigation of the Potentilla kleiniana led to the isolation of a new seco-nortriterpene, kleinianene (1), and eight known compounds including one phenylpropanoid glycoside (2), one lignan glycoside (3), one ellagic acid derivative (4), one phenylacetic acid derivative (5), one C₂₁-steroid (6), one polyhydroxyalkylpyrazine derivative (7), one quinoline derivative (8), and one phenolic acid (9). Their structures were elucidated by extensive spectroscopic methods and comparison with literature data. Moreover, the anti-inflammatory activity of 1 was evaluated by measuring its inhibitory effect on NO production in LPS-stimulated RAW 264.7 macrophages. The obtained result showed a moderate inhibition effect of NO release with IC₅₀ value of 26.88 ± 0.36 μM. All the above compounds were isolated from P. kleiniana for the first time and five compounds (2 and 5–8) were first reported from the family Rosaceae. Furthermore, the chemotaxonomic significance of the isolated compounds was discussed briefly.

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来源期刊

Biochemical Systematics and Ecology 生物-进化生物学

CiteScore

3.00

自引率

12.50%

发文量

147

审稿时长

43 days

期刊介绍： Biochemical Systematics and Ecology is devoted to the publication of original papers and reviews, both submitted and invited, in two subject areas: I) the application of biochemistry to problems relating to systematic biology of organisms (biochemical systematics); II) the role of biochemistry in interactions between organisms or between an organism and its environment (biochemical ecology). In the Biochemical Systematics subject area, comparative studies of the distribution of (secondary) metabolites within a wider taxon (e.g. genus or family) are welcome. Comparative studies, encompassing multiple accessions of each of the taxa within their distribution are particularly encouraged. Welcome are also studies combining classical chemosystematic studies (such as comparative HPLC-MS or GC-MS investigations) with (macro-) molecular phylogenetic studies. Studies that involve the comparative use of compounds to help differentiate among species such as adulterants or substitutes that illustrate the applied use of chemosystematics are welcome. In contrast, studies solely employing macromolecular phylogenetic techniques (gene sequences, RAPD studies etc.) will be considered out of scope. Discouraged are manuscripts that report known or new compounds from a single source taxon without addressing a systematic hypothesis. Also considered out of scope are studies using outdated and hard to reproduce macromolecular techniques such as RAPDs in combination with standard chemosystematic techniques such as GC-FID and GC-MS.