Coupled-Batch Preferential Crystallization of Imeglimin Propionate on a 200 g Scale

IF 3.5 3区化学 Q2 CHEMISTRY, APPLIED

Organic Process Research & Development Pub Date : 2025-01-08 DOI:10.1021/acs.oprd.4c0029110.1021/acs.oprd.4c00291

Leela Christian-Tabak*, Koji Machida, Hideo Kawachi, Hiroaki Tanaka and Kazuki Hashimoto,

引用次数: 0

Abstract

The application of coupled-batch preferential crystallization (CB-PC) for the propionate salt of the active pharmaceutical ingredient imeglimin is demonstrated herein. Process conditions were chosen based on metastable zone width measurements, and an apparatus with 500 mL-sized crystallization vessels was constructed. A series of CB-PC experiments on an increasing scale were run, and observations on scaling up were made throughout, including the effect of the seeding method, productivity over time, and physical limits of the apparatus. The series culminated in two successive runs each on a 200 g scale, in which the mother liquor from the first run was recycled to the second.

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200 g丙酸依米明的间歇优先结晶

本文介绍了双批优先结晶法（CB-PC）在活性药物成分伊美霉素丙酸盐制备中的应用。根据亚稳区宽度的测量选择了工艺条件，并构建了500 ml大小的结晶容器装置。在不断扩大的规模下进行了一系列的CB-PC实验，并对不断扩大的规模进行了观察，包括播种方法的影响、随时间的生产力以及设备的物理极限。该系列在连续两次运行中达到高潮，每次运行200克，其中第一次运行的母液被回收到第二次运行。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Process Research & Development 化学-应用化学

CiteScore

6.90

自引率

14.70%

发文量

251

审稿时长

2 months

期刊介绍： The journal Organic Process Research & Development serves as a communication tool between industrial chemists and chemists working in universities and research institutes. As such, it reports original work from the broad field of industrial process chemistry but also presents academic results that are relevant, or potentially relevant, to industrial applications. Process chemistry is the science that enables the safe, environmentally benign and ultimately economical manufacturing of organic compounds that are required in larger amounts to help address the needs of society. Consequently, the Journal encompasses every aspect of organic chemistry, including all aspects of catalysis, synthetic methodology development and synthetic strategy exploration, but also includes aspects from analytical and solid-state chemistry and chemical engineering, such as work-up tools，process safety, or flow-chemistry. The goal of development and optimization of chemical reactions and processes is their transfer to a larger scale; original work describing such studies and the actual implementation on scale is highly relevant to the journal. However, studies on new developments from either industry, research institutes or academia that have not yet been demonstrated on scale, but where an industrial utility can be expected and where the study has addressed important prerequisites for a scale-up and has given confidence into the reliability and practicality of the chemistry, also serve the mission of OPR&D as a communication tool between the different contributors to the field.