Integrated Modulation of Fe, Co-MOF Nanozymes for Expressing Peroxidase-like Activity: Enhanced Affinity for H2O2 and Analysis of Isoniazid

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2025-01-22 DOI:10.1021/acsmaterialslett.4c0256310.1021/acsmaterialslett.4c02563

Qijun Sun, Jie Yu, Renguo Zhang, Xueling Yu, Jiating Xu, Na Niu* and Ligang Chen*,

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Abstract

The limited affinity of horseradish peroxidase (HRP) for H₂O₂ makes it unsuitable for identifying situations containing trace amounts of H₂O₂. Herein, a set of regulation schemes for Fe, Co-MOF was proposed to develop a substitute for HRP. Regarding H₂O₂ adsorption, solvent engineering allowed the MIL framework to expose the (101) crystal plane with the highest density of Lewis acid sites, and the unsaturated center of the ligand generated by the Co sites on the 1D metal–oxygen chain facilitates the adsorption of H₂O₂ in sub-nanochannels. Regarding H₂O₂ reduction, ligand amination engineering created electron donor regions. Hydrogenation engineering increased the number of Fe²⁺ as catalytic centers, and the synergy between in situ modified tiny AuNPs and them reduced the activation energy of the peroxidase-like reaction. Ultimately, the affinity of Fe, Co-MOF for H₂O₂ was increased by 70 times compared with HRP. As a proof-of-concept, it was used to detect isoniazid, a typical antituberculosis drug, in human urine samples.

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.