{"title":"Diketopyrrolopyrrole-Based Nanoparticles with Near-Infrared Absorption for Tumor Photothermal Therapy","authors":"Tangyue Zheng, Hui Wen, Hongyu Wang, Qihang Wu*, Tingting Sun* and Zhigang Xie, ","doi":"10.1021/acsanm.5c0004010.1021/acsanm.5c00040","DOIUrl":null,"url":null,"abstract":"<p >Diketopyrrolopyrrole (DPP) is now widely used in the phototherapy of tumors, but most of the reported DPP molecules have no absorption in the near-infrared (NIR) region. In this study, 3 DPP derivatives with donor–acceptor–donor (D-A-D) structures were designed and synthesized, which were named OODPP, OSDPP, and SSDPP according to the number of thione groups. Their absorption spectra are gradually red-shifted with an increase in the number of thione groups. However, after the preparation of nanoparticles (NPs), OSDPP NPs show the maximum absorption red shift with an absorption peak at 786 nm and excellent photothermal performance under NIR laser irradiation. In addition, OSDPP NPs could more effectively inhibit tumor growth under irradiation. Therefore, this work provides a feasible method for the design of DPP-based phototherapeutic agents with red-shifted absorption for tumor therapy.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 4","pages":"2054–2061 2054–2061"},"PeriodicalIF":5.3000,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Nano Materials","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsanm.5c00040","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Diketopyrrolopyrrole (DPP) is now widely used in the phototherapy of tumors, but most of the reported DPP molecules have no absorption in the near-infrared (NIR) region. In this study, 3 DPP derivatives with donor–acceptor–donor (D-A-D) structures were designed and synthesized, which were named OODPP, OSDPP, and SSDPP according to the number of thione groups. Their absorption spectra are gradually red-shifted with an increase in the number of thione groups. However, after the preparation of nanoparticles (NPs), OSDPP NPs show the maximum absorption red shift with an absorption peak at 786 nm and excellent photothermal performance under NIR laser irradiation. In addition, OSDPP NPs could more effectively inhibit tumor growth under irradiation. Therefore, this work provides a feasible method for the design of DPP-based phototherapeutic agents with red-shifted absorption for tumor therapy.
期刊介绍：
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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