A Cell Adhesive Radial Nanofiber Membrane for Promoting Diabetes Wound Healing

IF 4.7 2区化学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Polymer Materials Pub Date : 2024-12-26 DOI:10.1021/acsapm.4c0298310.1021/acsapm.4c02983

Ning Wang, Tianyu Wang, Rongda Zhang, Ying Chen, Xiaojuan Yan, Ying Sui, Zequn Sun, Fujun Han, Wenyan Jiang, Lijie Duan* and Guanghui Gao*,

{"title":"A Cell Adhesive Radial Nanofiber Membrane for Promoting Diabetes Wound Healing","authors":"Ning Wang, Tianyu Wang, Rongda Zhang, Ying Chen, Xiaojuan Yan, Ying Sui, Zequn Sun, Fujun Han, Wenyan Jiang, Lijie Duan* and Guanghui Gao*, ","doi":"10.1021/acsapm.4c0298310.1021/acsapm.4c02983","DOIUrl":null,"url":null,"abstract":"<p >Diabetic wounds are extremely difficult to heal due to the long duration and high recurrence rate. The bacterial infection caused by elevated blood glucose negatively affects the speed of wound healing. In this article, radially oriented nanofibers containing the natural antimicrobial agent purslane were prepared by electrostatic spinning. Subsequently, asiaticoside was loaded onto the surface of the fibers by electrostatic spraying. The experimental results indicated that radial nanofiber membranes exhibited uniform diameter distribution, suitable water vapor permeability, and good hydrophilicity as well as excellent antibacterial performance and biocompatibility. Due to the ordered arrangement, the radial nanofibers exhibited good wound healing ability, regular granulation tissue growth, and high collagen deposition. More importantly, the radially oriented fiber structure significantly promoted cell proliferation and adhesion. Based on these results, nanofiber membranes with a radially oriented structure have potential application prospects in the field of chronic diabetic wound healing.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":"7 1","pages":"258–267 258–267"},"PeriodicalIF":4.7000,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Polymer Materials","FirstCategoryId":"92","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsapm.4c02983","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Diabetic wounds are extremely difficult to heal due to the long duration and high recurrence rate. The bacterial infection caused by elevated blood glucose negatively affects the speed of wound healing. In this article, radially oriented nanofibers containing the natural antimicrobial agent purslane were prepared by electrostatic spinning. Subsequently, asiaticoside was loaded onto the surface of the fibers by electrostatic spraying. The experimental results indicated that radial nanofiber membranes exhibited uniform diameter distribution, suitable water vapor permeability, and good hydrophilicity as well as excellent antibacterial performance and biocompatibility. Due to the ordered arrangement, the radial nanofibers exhibited good wound healing ability, regular granulation tissue growth, and high collagen deposition. More importantly, the radially oriented fiber structure significantly promoted cell proliferation and adhesion. Based on these results, nanofiber membranes with a radially oriented structure have potential application prospects in the field of chronic diabetic wound healing.

Abstract Image

查看原文本刊更多论文

促进糖尿病伤口愈合的细胞黏附径向纳米纤维膜

糖尿病创面持续时间长，复发率高，难以愈合。血糖升高引起的细菌感染会对伤口愈合速度产生负面影响。采用静电纺丝法制备了含有天然抗菌剂马齿苋的径向定向纳米纤维。随后，通过静电喷涂将积雪草苷加载到纤维表面。实验结果表明，径向纳米纤维膜具有直径分布均匀、透气性好、亲水性好、抗菌性能和生物相容性好的特点。由于排列有序，径向纳米纤维具有良好的伤口愈合能力，肉芽组织生长规律，胶原沉积量高。更重要的是，径向取向的纤维结构显著促进了细胞的增殖和粘附。基于这些结果，具有径向取向结构的纳米纤维膜在慢性糖尿病创面愈合领域具有潜在的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ACS Applied Polymer Materials Multiple-

CiteScore

7.20

自引率

6.00%

发文量

810

期刊介绍： ACS Applied Polymer Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics, and biology relevant to applications of polymers. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates fundamental knowledge in the areas of materials, engineering, physics, bioscience, polymer science and chemistry into important polymer applications. The journal is specifically interested in work that addresses relationships among structure, processing, morphology, chemistry, properties, and function as well as work that provide insights into mechanisms critical to the performance of the polymer for applications.