Development of MhOR1 as a Chemogenetic Tool for Odorant-Mediated Regulation of Insulin Release

Abstract

Our study presents MhOR1, an odorant-responsive chemogenetic tool that facilitates calcium influx upon odorant activation. We optimized its membrane expression and demonstrated its ability to regulate insulin release in pancreatic β cells. Our results suggest that MhOR1 holds potential for gene regulation and therapeutic applications through odorant-triggered cellular activities.