Aluminum promotes B1 cells to produce IL-10 and impairs adaptive immune system

IF 7.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2025-02-04 DOI:10.1016/j.envpol.2025.125791

Ting Liu , Wei Wang , Jun Du , Hongyue Liu , Jiaojiao Wu , Chuanxuan Wang , MengKe Tang , Yalin Liu , Yingzi Ju , Weidong Qu , Jianheng Zheng , Yifan Zhao , Yubin Zhang

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Abstract

Aluminum (Al) is a metal existing in the human body, yet the immunotoxicity of Al remains elusive. To investigate the immunotoxicity of Al, C57BL/6 mice were treated with 200 or 800 ppm Al via drinking water for 3 months, and thereafter the adaptive immune system was evaluated. In addition, mouse splenocytes and human peripheral blood mononuclear cells (PBMC) were treated with Al in vitro to assess the impact of Al in vitro. Treatment with Al reduced the production of IgM and IgG in the serum, and the activation of B cells, CD4 T cells and CD8 T cells in the spleen of mice; treatment with Al in vitro suppressed the production of IgM and IgG, and the activation of B cells, CD4 T cells and CD8 T cells in mouse splenocytes and human PBMC. In vitro co-culture assays suggested that the suppressed adaptive immunity was due to B cells modified by Al. In terms of mechanism, a direct action of Al on B1 cells induced the B1 cells to be IL-10-producing cells and thereby suppressed the adaptive immune system, which was critically dependent on the Jak1/3-STAT signaling. This study reveals that Al suppresses the adaptive immunity via induction of IL-10-producing B1 cells.

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铝促进B1细胞产生IL-10，损害适应性免疫系统

铝（Al）是一种存在于人体内的金属，其免疫毒性尚不清楚。为了研究Al对C57BL/6小鼠的免疫毒性作用，分别以200 ppm和800 ppm的Al为饮水剂量，对C57BL/6小鼠进行3个月的适应性免疫系统评价。此外，用Al体外处理小鼠脾细胞和人外周血单个核细胞（PBMC），以评估Al的体外影响。Al处理可降低小鼠血清IgM和IgG的产生，降低脾脏B细胞、CD4 T细胞和CD8 T细胞的活化；体外Al处理可抑制小鼠脾细胞和人PBMC中IgM和IgG的产生，以及B细胞、CD4 T细胞和CD8 T细胞的活化。体外共培养实验表明，适应性免疫的抑制是由Al修饰的B细胞引起的。从机制上看，Al直接作用于B1细胞，诱导B1细胞成为产生il -10的细胞，从而抑制了严重依赖于Jak1/3-STAT信号的适应性免疫系统。本研究表明，Al通过诱导产生il -10的B1细胞抑制适应性免疫。

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.