Protective Effects of Korean Red Ginseng Against Oxidative Stress-Induced Damage in Human Hair.

Annals of dermatology Pub Date : 2025-02-01 DOI:10.5021/ad.24.047

Seung-Won Jung, Long-Quan Pi, Jae Joon Jeon, You Hyun Kim, Solam Lee, Won-Soo Lee

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Abstract

Background: Oxidative stress causes fatal damage to follicular keratinocytes (FKCs) and is a common pathophysiology of many hair disorders.

Objective: This study investigated the protective effects of Red ginseng extract (RGE) and its main ginsenosides against oxidative hair damage using an in vitro organ model of human hair follicles.

Methods: We examined whether RGE and its constituent ginsenosides could prevent oxidative damage induced by H₂O₂ in FKCs by suppressing apoptosis and promoting hair growth.

Results: RGE and its main ginsenoside, G-Rb1, significantly inhibited reactive oxygen species production and apoptosis in FKCs. Furthermore, they effectively alleviated the inhibition of hair growth induced by oxidative damage and inhibited the transition of hair from the anagen to the telogen stage. The hair cycle and apoptosis were associated with the modulation of p53 and Bax/Bcl2 signaling.

Conclusion: RGE and G-Rb1 can effectively mitigate the oxidative damage caused by FKCs, thereby affecting hair growth and hair cycles.

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红参对头发氧化应激损伤的保护作用。

背景：氧化应激对毛囊角质形成细胞（FKCs）造成致命损伤，是许多头发疾病的常见病理生理机制。目的：研究红参提取物及其主要皂苷对人毛囊体外器官模型氧化性头发损伤的保护作用。方法：观察金黄酮及其人参皂苷是否能通过抑制细胞凋亡和促进毛发生长来预防h2o2诱导的FKCs氧化损伤。结果：RGE及其主要人参皂苷G-Rb1显著抑制FKCs活性氧的产生和细胞凋亡。此外，它们还能有效缓解氧化损伤对毛发生长的抑制作用，抑制毛发从生长期向休止期的过渡。毛发周期和细胞凋亡与p53和Bax/Bcl2信号的调控有关。结论：RGE和G-Rb1可有效减轻FKCs引起的氧化损伤，从而影响头发生长和头发周期。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Annals of dermatology

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