Antiviral activity of ribosome inactivating proteins for management of plant viral infection

IF 2.8 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-02-01 DOI:10.1016/j.virol.2025.110403

Pooja Bhardwaj , Baswaraj Raigond , Pinky Raigond , Ambika Verma , Gaurav Verma , Tarvinder Kochhar , Parashuram Patroti , I.K. Das , C Tara Satyavathi

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Abstract

In nature, plants exhibit various defense mechanisms to protect themselves from viral infection. Reported to harbor virus-inhibiting compounds like Ribosome inactivating proteins (RIPs). It's a matter of how we explore, identify, and utilize RIPs in managing a given stress. RIPs have been found to contain antiviral, anticancer, and neurotoxic effects and are used in various biomedical and agricultural fields. The expression of RIPs could be enhanced in plants to improve their defense against biotic and abiotic stresses. Identification of new RIPs and genetic sequencing led to the development of new phylogenetic theories. Studies on the interaction between RIPs and cells have increased the knowledge regarding the handling of exogenous proteins by cells. The review provides a brief historical preview, classification, mode of action, and broader applications with a special focus on managing plant viral diseases and concerns to mankind.

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.