Antiviral activity of ribosome inactivating proteins for management of plant viral infection

IF 2.8 3区医学 Q3 VIROLOGY

Virology Pub Date : 2025-02-01 DOI:10.1016/j.virol.2025.110403

Pooja Bhardwaj , Baswaraj Raigond , Pinky Raigond , Ambika Verma , Gaurav Verma , Tarvinder Kochhar , Parashuram Patroti , I.K. Das , C Tara Satyavathi

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引用次数: 0

Abstract

In nature, plants exhibit various defense mechanisms to protect themselves from viral infection. Reported to harbor virus-inhibiting compounds like Ribosome inactivating proteins (RIPs). It's a matter of how we explore, identify, and utilize RIPs in managing a given stress. RIPs have been found to contain antiviral, anticancer, and neurotoxic effects and are used in various biomedical and agricultural fields. The expression of RIPs could be enhanced in plants to improve their defense against biotic and abiotic stresses. Identification of new RIPs and genetic sequencing led to the development of new phylogenetic theories. Studies on the interaction between RIPs and cells have increased the knowledge regarding the handling of exogenous proteins by cells. The review provides a brief historical preview, classification, mode of action, and broader applications with a special focus on managing plant viral diseases and concerns to mankind.

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核糖体灭活蛋白在植物病毒感染管理中的抗病毒活性。

在自然界中，植物表现出各种防御机制来保护自己免受病毒感染。据报道含有病毒抑制化合物，如核糖体失活蛋白（RIPs）。这是一个我们如何探索、识别和利用rip来管理给定压力的问题。rip已被发现含有抗病毒、抗癌和神经毒性作用，并被用于各种生物医学和农业领域。ripps的表达可以提高植物对生物和非生物胁迫的防御能力。新的rip的鉴定和基因测序导致了新的系统发育理论的发展。对rip和细胞之间相互作用的研究增加了关于细胞处理外源蛋白的知识。本文简要介绍了植物病毒病的历史概况、分类、作用方式和广泛应用，重点介绍了植物病毒病的防治和人类关注的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virology 医学-病毒学

CiteScore

6.00

自引率

0.00%

发文量

157

审稿时长

50 days

期刊介绍： Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.