Immunomodulatory and bone regenerative properties of copper/procyanidins-modified titanium surfaces

IF 5.5 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-01-23 DOI:10.1016/j.bioadv.2025.214199

Rongxin Wan , Wenbo Li , Kuo Yang , Lijun Li , Shaojing Wang , Li Lei , Huiqin Tang , Hanqing Gu

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引用次数: 0

Abstract

The inflammatory response triggered by the interaction between implants and macrophages is essential for bone regeneration around these implants. This study presents the application of dopamine hydrochloride to develop a copper and procyanidins coating on titanium surfaces to investigate its effects on bacterial inhibition, macrophage polarization, and osteogenic differentiation. The results demonstrated that this copper/procyanidins coating significantly suppressed the growth of Escherichia coli and Staphylococcus aureus. Notably, the initial release of Cu²⁺ ions promoted macrophage polarization toward a pro-inflammatory phenotype while stimulating the secretion of anti-inflammatory factors. Subsequently, the reduced Cu²⁺ release combined with procyanidins facilitated the transition from M1 to M2 macrophages—an essential process for bacterial phagocytosis and bone regeneration. Furthermore, this coating enhanced the secretion of osteogenic factors by bone marrow mesenchymal stem cells, enhancing their osteogenic differentiation and integration with bone tissue. These findings highlight the potential of copper/procyanidins coating in developing implant surfaces with immune-modulating and sustained antibacterial properties.

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!