Relationship between uric acid to HDL ratio and extent and severity of coronary artery disease.

Abstract

Introduction: Coronary artery disease (CAD) is common worldwide and is a significant cause of morbidity and mortality. CAD is a chronic and inflammatory disease mainly caused by atherosclerosis. SYNTAX and Gensini scoring systems are used to evaluate CAD extent and severity. Uric acid to high-density lipoprotein (HDL) ratio (UHR) increases in inflammatory conditions.

Aim: To investigate the relationship between UHR and the extent and severity of CAD and its correlation with SYNTAX and Gensini scoring systems.

Material and methods: 894 patients who underwent angiography were included in the study. 612 participants with critical coronary stenosis were designated as the patient group, and 282 participants without stenosis were designated as the control group. Characteristic features and laboratory parameters of the groups were compared. The relationship between the SYNTAX and Gensini scores of the patient group and UHR was analyzed.

Results: Baseline characteristics and laboratory parameters were similar in both groups, except for uric acid and UHR levels. Both uric acid levels (7.58 ±2.55 mg/dl vs. 5.71 ±1.46 mg/dl, p < 0.01) and UHR (0.2016 ±0.094 vs. 0.1461 ±0.05, p < 0.01) were significantly higher in the patient group. UHR levels were found to be correlated significantly with both scoring systems. In the ROC curve analysis the UHR cut-off value of 0.1567 was able to predict CAD moderately (AUC = 0.669 (0.634-0.704), sensitivity 61.1%, specificity 38.7%).

Conclusions: UHR is an easy-to-use parameter that can be used before invasive evaluation to predict the presence, severity, and extent of CAD.