Long-Chain Polyunsaturated Fatty Acids and Painful Temporomandibular Disorder in the Hispanic Community Health Study/Study of Latinos.

IF 3 3区医学 Q2 NUTRITION & DIETETICS

Public Health Nutrition Pub Date : 2025-02-03 DOI:10.1017/S1368980025000102

Anne E Sanders, Jianwen Cai, Martha L Daviglus, Olga Garcia-Bedoya, Gary D Slade

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引用次数: 0

Abstract

Objective: Omega-6 and omega-3 long-chain polyunsaturated fatty acids (PUFAs) play opposing roles in inflammation, anxiety, and nociception, all of which are closely associated with chronic pain. We hypothesized that diets high in omega-6 arachidonic acid (C20:4n-6, AA) and low in combined omega-3 eicosapentaenoic acid (C20:5n-3, EPA) and docosahexaenoic acid (C22:6n-3, DHA) would be associated with higher odds of painful temporomandibular disorder (TMD).

Design: We analyzed baseline data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Two 24-hr dietary recall surveys quantified intake of long-chain omega-6 and omega-3 PUFAs along with their precursors, linoleic acid (C18:2n-6, LA) and alpha linolenic acid (C18:3n-3, ALA) respectively. Omega-3 PUFAs supplementation was quantified. Interviewer-administered questions assessed TMD. Survey multiple logistic regression estimated covariate-adjusted odds ratios (OR) and 95% confidence limits (CL) for associations between PUFAs and TMD.

Setting: From 2008-2011, HCHS/SOL recruited 16,415 adults of Hispanic/Latino backgrounds (Cuban, Puerto Rican, Dominican, Mexican, Central/South American), through field centers located in Miami, FL; San Diego CA; Chicago, IL; and the Bronx, NY.

Participants: 13,870 participants with non-missing data.

Results: In analysis adjusted for covariates, each standard deviation increase in dietary intake of C20:4n-6, AA was associated with 12% higher odds of TMD (OR=1.12, CL:1.01, 1.24). Although the dietary intake of combined long-chain C20:5n-3, EPA and C22:6n-3 DHA was not associated with TMD, each standard deviation increase in omega-3 dietary supplement was associated with lower odds of TMD.

Conclusions: A diet rich in C20:4n-6, AA was associated with higher odds of painful TMD.

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来源期刊

Public Health Nutrition 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.10

自引率

6.20%

发文量

521

审稿时长

3 months

期刊介绍： Public Health Nutrition provides an international peer-reviewed forum for the publication and dissemination of research and scholarship aimed at understanding the causes of, and approaches and solutions to nutrition-related public health achievements, situations and problems around the world. The journal publishes original and commissioned articles, commentaries and discussion papers for debate. The journal is of interest to epidemiologists and health promotion specialists interested in the role of nutrition in disease prevention; academics and those involved in fieldwork and the application of research to identify practical solutions to important public health problems.