Acoustic prosodic parameters associated with Parkinson's disease cognitive impairment

Abstract

Background

Acoustic prosodic analysis is a novel approach that can be used to identify patients with mild cognitive impairment (MCI) and dementia in Alzheimer's disease (AD). We hypothesize that acoustic analysis can also differentiate cognitive impairment in Parkinson's disease (PD).

Methods

We investigated acoustic parameters in 90 subjects including 30 PD with normal cognition (PD-NC), 30 PD with mild cognitive impairment (PD-MCI) and 30 PD with dementia (PDD). The reading task “Supermarket Passage” and the picture description task “Cookie Theft” were used. Feature selection and modelling were then performed to systematically evaluate the importance and clinical implications of the acoustic parameters in identifying PD with cognitive impairment.

Results

Analysis of covariance (ANCOVA) and mediation analysis revealed that acoustic parameters were independently associated with cognitive impairment including PDD and PD-MCI. These Acoustic parameters enabled the detection of PD with cognitive impairment with an area under the receiver operating characteristic curve (AUC) of 0.826. Compared with PD-NC, speech rate, pre-verb pause (≥1s), between-utterance pause (≥2s) in the “Cookie Theft” task were the two key cognitive impairment detection factors, which were frequently identified by LASSO model in both PDD and PD-MCI. F₀SD of interrogative sentence was often selected in PDD. In feature selection, AUC was 0.944 in discriminating PDD from PD-NC and AUC was 0.753 in discriminating PD-MCI from PD-NC.

Conclusion

We demonstrated that acoustic parameters are useful in differentiating PD patients with cognitive impairment from patients with normal cognition after adjusting variables such as age, which was also a significant contributor to cognitive decline. Acoustic parameters may be valuable for automated screening the risk of cognitive decline in PD patients. It deserves further investigation.