Does Schistosoma mansoni trigger colorectal cancer?

IF 1.4 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Sidhant Jain
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引用次数: 0

Abstract

In this work the relationship between Schistosoma mansoni (Sm) and the induction and progression of colorectal cancer (CRC) is examined. Various clinical studies reviewed here yield inconsistent results, with some reporting no association between Sm infection and CRC and others suggesting a probable to strong association. Here we propose a number of plausible mechanisms whereby Sm infection might contribute to CRC induction and/or progression. These factors are (1) chronic inflammation, (2) exposure to parasite linked antigens and genotoxic products, especially soluble egg antigens (SEAs) and (3) alteration of the intestinal microbiota. These factors probably predispose humans towards CRC and can help in CRC progression however only widespread epidemiological, clinical and pathological studies can firmly establish their role or a complete lack of it.
曼氏血吸虫会引发结直肠癌吗?
本文研究了曼氏血吸虫(Sm)与结直肠癌(CRC)的诱导和发展之间的关系。本文回顾的各种临床研究得出了不一致的结果,一些研究报告Sm感染与CRC之间没有关联,而另一些研究则表明可能有很强的关联。在这里,我们提出了一些可能的机制,其中Sm感染可能有助于CRC的诱导和/或进展。这些因素是:(1)慢性炎症,(2)暴露于寄生虫相关抗原和基因毒性产物,特别是可溶性卵抗原(SEAs),以及(3)肠道微生物群的改变。这些因素可能使人类易患结直肠癌,并有助于结直肠癌的进展,但只有广泛的流行病学、临床和病理研究才能确定它们的作用或完全缺乏。
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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
51
审稿时长
63 days
期刊介绍: The journal provides a medium for rapid publication of investigations of the molecular biology and biochemistry of parasitic protozoa and helminths and their interactions with both the definitive and intermediate host. The main subject areas covered are: • the structure, biosynthesis, degradation, properties and function of DNA, RNA, proteins, lipids, carbohydrates and small molecular-weight substances • intermediary metabolism and bioenergetics • drug target characterization and the mode of action of antiparasitic drugs • molecular and biochemical aspects of membrane structure and function • host-parasite relationships that focus on the parasite, particularly as related to specific parasite molecules. • analysis of genes and genome structure, function and expression • analysis of variation in parasite populations relevant to genetic exchange, pathogenesis, drug and vaccine target characterization, and drug resistance. • parasite protein trafficking, organelle biogenesis, and cellular structure especially with reference to the roles of specific molecules • parasite programmed cell death, development, and cell division at the molecular level.
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