Causal Association Between Chronic Inflammatory Arthropathies and Sarcopenia and the Mediation Role of Inflammatory Factors

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2025-02-02 DOI:10.1111/1756-185X.70100

Yanyan Qian, Xiaowei Wang, Chen Zhu, Qiang Tong, Jianzheng Zhang, Shengjie Zhao

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引用次数: 0

Abstract

Background

Although chronic inflammatory arthropathies (CIA) are associated with sarcopenia, sarcopenia plays a role in their pathogenesis remains unknown. This study investigated the causal relationship between sarcopenia and CIA and to identify potential mediating factors.

Methods

We examined data from 458 910 participants in the UK Biobank to analyze the association between sarcopenia-related traits and CIA. Associations between hand-grip strength, muscle mass, walking pace, and CIA were analyzed using Cox regression models. Then, we performed a mediation analysis to explore the underlying mechanisms.

Results

Individuals with low hand-grip strength exhibited a 1.88-fold (95% CI 1.73–2.05), 2.22-fold (95% CI 2.02–2.45), and 1.36-fold (95% CI 1.32–1.41) increased risk of rheumatoid arthritis (RA), spondyloarthritis (SpA), and osteoarthritis (OA), respectively. The HRs for sarcopenia were 1.64 (95% CI 1.15–2.32) for RA, 1.83 (95% CI 1.21–2.77) for SpA, and 1.26 (95% CI 1.09–1.45) for OA. Additionally, individuals with a slow walking pace exhibited a 1.83-fold (95% CI 1.66–2.02), 3.58-fold (95% CI 3.25–3.95), and 1.82-fold (95% CI 1.77–1.88) increased risk of RA, SpA, and OA, respectively. Furthermore, we identified inflammatory markers as possible mediators of the causal effects of low hand-grip strength on the development of CIA.

Conclusions

Our findings suggest that sarcopenia is independently associated with an increased risk of CIA, which is partially mediated by inflammation factors.

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.