Clinical Outcomes of Two Lenticule Thickness Types in Descemet Stripping Automated Endothelial Keratoplasty: One-Year Results.

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Neal Rangu, Michael Heath, Michael Szkarlat, Kai Ding, Roya Garakani, Kenan Bakri, Evan Pike, Hooman Harooni, Christopher Chow, Surendar Dwarakanathan, Liam Redden, Kamran M Riaz
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Abstract

Purpose: To compare clinical outcomes of eyes undergoing Descemet stripping automated endothelial keratoplasty (DSAEK) with 51-99 μm and <50 μm lenticules.

Methods: Retrospective, multi-center case series of 480 eyes undergoing DSAEK with precut tissue from a single eye bank between 2019 and 2022 performed by five surgeons at five centers. Eyes were divided into 51-99 μm or <50 μm groups according to post-cut graft thickness. The main outcome measure was inter-group comparison according to best-corrected distance visual acuity (BCDVA); additional outcome measures were primary graft failure (PGF), rebubbling, and cystoid macular edema (CME) rates in context of specific preoperative risk factors, intraoperative characteristics, and vision-limiting vs. non-vision-limiting morbidities.

Results: BCDVA at one year postoperatively was 0.5 ± 0.5 and 0.4 ± 0.4 logMAR for the 51-99 μm and <50 μm groups, respectively (p = 0.692). Regraft rate was 3.21% for 51-99 μm and 1.89% for <50 μm grafts (p = 0.4854). Rebubbling rate was 8.56% for the 51-99 μm group and 13.21% for the <50 μm group (p = 0.151). Analysis of rebubbled eyes showed no difference in rate of sulfur hexafluoride tamponade (p = 0.201), lenticule insertion method (p = 0.293), and glaucoma surgery history (p = 0.996). Higher rebubbling rates occurred in eyes with previous scleral-fixated intraocular lenses (p < 0.001). The effect of potential preoperative and intraoperative risk factors (e.g. insertion method (p = 0.979) and concurrent cataract surgery (p = 0.701)) on rebubbling was not significantly different between the two groups. CME rate was 4.01% for 51-99 μm and 7.54% for <50 μm groups (p = 0.131).

Conclusions: 51-99 μm and <50 μm DSAEK grafts offer similar visual outcomes. Both lenticule thicknesses have similar regrafting, rebubbling, and CME rates.

两种晶状体厚度类型在角膜剥离自动内皮角膜移植术中的临床结果:一年的结果。
目的:比较51-99 μm角膜内皮剥离自动角膜移植术(DSAEK)的临床效果。方法:回顾性,多中心病例系列,包括2019年至2022年间由5个中心的5名外科医生在单个眼库中使用预切组织进行的480只眼睛的DSAEK。结果:51 ~ 99 μm眼术后1年BCDVA分别为0.5±0.5和0.4±0.4 logMAR (p = 0.692)。51 ~ 99 μm的复植率为3.21%,p = 0.4854的复植率为1.89%)。51 ~ 99 μm组的复泡率为8.56%,p = 0.151组为13.21%)。再泡眼分析显示,六氟化硫填塞率(p = 0.201)、晶状体插入方式(p = 0.293)、青光眼手术史(p = 0.996)差异无统计学意义。既往巩膜固定人工晶状体组(p = 0.979)和同期白内障手术组(p = 0.701)的再泡率较高,两组间无显著差异。51 ~ 99 μm的CME率为4.01%,p = 0.131的CME率为7.54%。结论:51 ~ 99 μm
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Eye Research
Current Eye Research 医学-眼科学
CiteScore
4.60
自引率
0.00%
发文量
163
审稿时长
12 months
期刊介绍: The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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