Causal Association Between Skin Microbiota and Malignant Melanoma: Genetic Insights From Mendelian Randomization.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-28 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S500172

Xianglong Li, Shuang Wu, Yujie Pan, Ziyan Wu, Zhong Du, Wanying Xie, Qingyu Zhou

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引用次数: 0

Abstract

Background: Malignant melanoma (MM) is an extremely aggressive type of skin cancer that represents a major risk to human health. Earlier observational research has indicated that skin microbiota could play a role in the development and advancement of MM. Nevertheless, the causal link between skin microbiota and MM is still unclear.

Methods: Utilizing data from genome-wide association studies (GWAS) conducted on a European cohort, we applied Mendelian randomization (MR) to evaluate the causal link between skin microbiota and MM. The analysis involved various MR methodologies, including inverse variance weighting (IVW), MR-Egger regression, weighted median, weighted mode and simple mode. Furthermore, we performed sensitivity analysis employing the intercept test of MR-Egger, the Cochran's Q test, the MR-PRESSO approach, and a leave-one-out method.

Results: By conducting MR analysis on the KORA FF4 cohort, we identified several skin microbiotas (ASV003 [Staphylococcus (unc).], ASV016 [Enhydrobacter (unc).], and ASV021 [Micrococcus (unc).]) related with an elevated risk of MM. Conversely, genus: Finegoldia and class: Alphaproteobacteria were shown to inhibit the occurrence of MM. Additionally, MR analysis of the PopGen cohort revealed that ASV021 [Micrococcus (unc).] and family: Moraxellaceae were identified as possible risk factors for MM.

Conclusion: Our research offers new insights into the connection between skin microbiota and MM, indicating that skin microbiota might affect the onset and advancement of MM. Therefore, focusing on skin microbiota could be a valuable strategy for the prevention, identification, and management of MM.

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.