Evolution of Hybrid Inviability Associated With Chromosome Fusions.

IF 4.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jesper Boman, Karin Näsvall, Roger Vila, Christer Wiklund, Niclas Backström
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引用次数: 0

Abstract

Chromosomal rearrangements, such as inversions, have received considerable attention in the speciation literature due to their hampering effects on recombination. Less is known about how other rearrangements, such as chromosome fissions and fusions, can affect the evolution of reproductive isolation. Here, we use crosses between populations of the wood white butterfly (Leptidea sinapis) with different karyotypes to identify genomic regions associated with hybrid inviability. We map hybrid inviability candidate loci by contrasting allele frequencies between F2 hybrids that survived until the adult stage with individuals of the same cohort that succumbed to hybrid incompatibilities. Hybrid inviability candidate regions have high genetic differentiation between parental populations, reduced recombination rates, and are enriched near chromosome fusions. By analysing sequencing coverage, we exclude aneuploidies as a direct link between hybrid inviability and chromosome fusions. Instead, our results point to an indirect relationship between hybrid inviability and chromosome fusions, possibly related to reduced recombination in fused chromosomes. Thus, we map postzygotic isolation to chromosomal rearrangements, providing crucial empirical evidence for the idea that chromosome number differences between taxa can contribute to speciation.

与染色体融合相关的杂交不育进化。
染色体重排,如倒位,由于它们对重组的阻碍作用,在物种形成文献中受到了相当大的关注。至于染色体分裂和融合等其他重排如何影响生殖隔离的进化,我们所知甚少。在这里,我们使用不同核型的木白蝶(Leptidea sinapis)群体之间的杂交来鉴定与杂交不生存相关的基因组区域。我们通过对比存活至成虫期的F2杂交种与同一群体中屈服于杂交种不亲和性的个体之间的等位基因频率,来绘制杂交种无活力候选位点。杂种不育候选区域在亲本群体之间具有较高的遗传分化,重组率较低,并且在染色体融合附近富集。通过分析测序覆盖率,我们排除了非整倍体作为杂种不育和染色体融合之间的直接联系。相反,我们的研究结果指出了杂交不育和染色体融合之间的间接关系,可能与融合染色体中重组的减少有关。因此,我们将受精卵后分离与染色体重排联系起来,为分类群之间染色体数目差异有助于物种形成的观点提供了重要的经验证据。
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来源期刊
Molecular Ecology
Molecular Ecology 生物-进化生物学
CiteScore
8.40
自引率
10.20%
发文量
472
审稿时长
1 months
期刊介绍: Molecular Ecology publishes papers that utilize molecular genetic techniques to address consequential questions in ecology, evolution, behaviour and conservation. Studies may employ neutral markers for inference about ecological and evolutionary processes or examine ecologically important genes and their products directly. We discourage papers that are primarily descriptive and are relevant only to the taxon being studied. Papers reporting on molecular marker development, molecular diagnostics, barcoding, or DNA taxonomy, or technical methods should be re-directed to our sister journal, Molecular Ecology Resources. Likewise, papers with a strongly applied focus should be submitted to Evolutionary Applications. Research areas of interest to Molecular Ecology include: * population structure and phylogeography * reproductive strategies * relatedness and kin selection * sex allocation * population genetic theory * analytical methods development * conservation genetics * speciation genetics * microbial biodiversity * evolutionary dynamics of QTLs * ecological interactions * molecular adaptation and environmental genomics * impact of genetically modified organisms
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