An optical coherence tomography study of a photoactive Pt(iv) prodrug in oesophageal tissue†

IF 4.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

RSC Advances Pub Date : 2025-01-31 DOI:10.1039/D4RA08693G

Huayun Shi, Muktesh Mohan, Kanwarpal Singh and Peter J. Sadler

引用次数: 0

Abstract

Photoactive diazido Pt(IV) complexes display in vivo anticancer efficacy towards oesophageal tumours, a worldwide common cancer. Here we explore the use of optical coherence tomography (OCT) as a new method for detecting tissue penetration and damage produced by the photoactivatable anticancer complex trans,trans,trans-[Pt(pyridine)₂(N₃)₂(OH)₂] (FM190). Dehydration of the sample and a change in refractive index were observed for swine oesophageal tissue treated with FM190 and blue laser light (445 nm) using an OCT system. In contrast, tissues treated with FM190 or laser light alone showed no apparent damage.

Abstract Image

查看原文本刊更多论文

食道组织中光活性铂（iv）前药的光学相干断层扫描研究。

光活性二氮多铂（iv）配合物对食管癌（一种世界范围内常见的癌症）显示出体内抗癌效果。在这里，我们探索使用光学相干断层扫描（OCT）作为检测由光活化抗癌复合物trans，trans,trans-[Pt（吡啶）2(N3)2(OH)2] （FM190）产生的组织穿透和损伤的新方法。利用OCT系统观察了FM190和445 nm蓝光处理后猪食管组织的脱水情况和折射率变化。相比之下，FM190或激光单独处理的组织没有明显的损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

RSC Advances chemical sciences-

CiteScore

7.50

自引率

2.60%

发文量

3116

审稿时长

1.6 months

期刊介绍： An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.