Clinicopathological Significance of Extranodal Extension in Hypopharyngeal and Laryngeal Squamous Cell Carcinoma

IF 2.3 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-01-31 DOI:10.1002/hed.28090

Natsumi Kijima, Yui Uzawa, Yuri Hirai, Yusuke Nojima, Jun Aoyama, Hideaki Takahashi, Yasuhiro Arai, Daisuke Sano, Goshi Nishimura, Nobuhiko Oridate, Satoshi Fujii

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Abstract

Background

The AJCC cutoff value of 2 mm for the extranodal extension (ENE) distance was determined from an analysis of patients with or without adjuvant therapy. The purpose of this study was to find out the ENE distance that reflects prognosis only in patients with head and neck squamous cell carcinoma (SCC) who received adjuvant therapy.

Methods

The ENE distance was defined for 109 patients who underwent surgery for SCC of larynx or hypopharynx as a primary tumor.

Results

To standardize patient conditions, only 26 patients who received additional postoperative treatment were analyzed. Receiver operating characteristic analysis of the ENE distance for overall survival (OS) and recurrence-free survival (RFS) yielded a cutoff value of 4250 μm. Multivariate analysis showed that the ENE distance was an independent poor prognostic factor for OS and RFS.

Conclusion

The optimal ENE distance cutoff for OS and RFS in postoperatively treated patients was 4250 μm.

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下咽喉部鳞癌结外延伸的临床病理意义。

背景：结外延伸（ENE）距离的AJCC截断值2mm是通过对接受或未接受辅助治疗的患者的分析确定的。本研究的目的是寻找仅能反映头颈部鳞状细胞癌（SCC）辅助治疗患者预后的ENE距离。方法：对109例喉部或下咽鳞状细胞癌作为原发肿瘤接受手术的患者确定ENE距离。结果：为了规范患者情况，我们只分析了26例接受术后额外治疗的患者。总生存期（OS）和无复发生存期（RFS）的ENE距离的接受者工作特征分析得出的截止值为4250 μm。多因素分析显示，ENE距离是OS和RFS的独立不良预后因素。结论：术后OS和RFS的最佳ENE距离临界值为4250 μm。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.