Prevalence of anti-nuclear antibodies in COVID-19 patients: a remarkable 2.5-fold rise compared to healthy controls.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Irish Journal of Medical Science Pub Date : 2025-02-01 DOI:10.1007/s11845-025-03886-8

Faruk Dişli, Sedat Yıldız

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引用次数: 0

Abstract

Background: The SARS-CoV-2 virus, responsible for COVID-19, has the potential to induce the formation of antibodies that target self-antigens. This study aimed to investigate the prevalence of antinuclear antibodies (ANA), the most common type of autoantibody, in both healthy individuals and those recovered from COVID-19.

Methods: This retrospective study involved 400 participants (200 with COVID-19 and 200 healthy controls), aged 18 to 60 years, without any chronic diseases, including autoimmune conditions. Analyses were performed using three different ANA ELISA test kits (anti-dsDNA, anti-ENA, and anti-Hep-2 nucleus tests) that were developed and validated.

Results: Among the 200 healthy individuals, 38 (19%) tested positive for dsDNA, 37 (18.5%) for ENA, and 30 (15%) for Hep-2 nucleus antibodies. The rates of ANA positivity were significantly higher in individuals with COVID-19, with 97 (48.5%) positive for dsDNA, 81 (40.5%) for ENA, and 84 (42%) for Hep-2 nucleus antibodies (p < 0.05).

Conclusion: One in every two to three individuals with COVID-19 exhibited ANA positivity, indicating that the SARS-CoV-2 virus poses a significant risk regarding autoimmunity. Furthermore, the incidence of ANA in healthy individuals was observed to be higher than the literature average.

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COVID-19患者的抗核抗体患病率：与健康对照组相比，显著上升2.5倍。

背景：导致COVID-19的SARS-CoV-2病毒有可能诱导形成针对自身抗原的抗体。本研究旨在调查健康个体和COVID-19康复者中最常见的自身抗体类型抗核抗体（ANA）的流行情况。方法：本回顾性研究纳入了400名参与者（200名COVID-19患者和200名健康对照），年龄在18至60岁之间，无任何慢性疾病，包括自身免疫性疾病。使用开发并验证的三种不同的ANA ELISA检测试剂盒（抗dsdna、抗ena和抗hep -2细胞核检测）进行分析。结果：200名健康个体中，38人（19%）检测出dsDNA阳性，37人（18.5%）检测出ENA阳性，30人（15%）检测出Hep-2核抗体阳性。在COVID-19患者中，ANA阳性率明显更高，dsDNA阳性97例（48.5%），ENA阳性81例（40.5%），Hep-2核抗体阳性84例（42%）(p结论：每2至3例COVID-19患者中就有1例ANA阳性，表明SARS-CoV-2病毒对自身免疫具有显著风险。此外，健康个体的ANA发病率高于文献平均水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Irish Journal of Medical Science 医学-医学：内科

CiteScore

3.70

自引率

4.80%

发文量

357

审稿时长

4-8 weeks

期刊介绍： The Irish Journal of Medical Science is the official organ of the Royal Academy of Medicine in Ireland. Established in 1832, this quarterly journal is a contribution to medical science and an ideal forum for the younger medical/scientific professional to enter world literature and an ideal launching platform now, as in the past, for many a young research worker. The primary role of both the Academy and IJMS is that of providing a forum for the exchange of scientific information and to promote academic discussion, so essential to scientific progress.