Lipidomics-based investigation of its impact on the pathogenesis of coronary atherosclerosis: a Mendelian randomization study.

IF 2.7 3区生物学

Hereditas Pub Date : 2025-02-01 DOI:10.1186/s41065-025-00367-x

Qun Wang, Yuan Cao, Lianqun Jia

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引用次数: 0

Abstract

Background: Considerable attention has been devoted to investigating the association between lipid metabolites and cardiovascular diseases, particularly coronary atherosclerosis.

Methods: A two-sample MR framework was used to investigate the relationship between lipid metabolites and the risk of coronary atherosclerosis. Two GWAS datasets were examined to take intersections of SNPs from 51,589 cases and 343,079 controls, and 14,334 cases and 346,860 controls to determine genetic susceptibility to coronary atherosclerosis. Random-effects inverse variance weighted (IVW) MR analyses were performed by a series of sensitivity assessments to measure the robustness of our findings and to detect any violations of MR assumptions.

Results: Through IVW, MR-Egger and weighted median regression methods, we inferred that these six lipid metabolites: cholesterol levels, sterol ester (27:1/18:2) levels, triacylglycerol (52:4) levels, triacylglycerol (52:5) levels, diacylglycerol (18:1_18.2) levels, triacylglycerol (53:4), could directly impact the development of atherosclerosis.

Conclusion: In conclusion, our study comprehensively illustrates a causal relationship between lipid metabolites and the risk of coronary atherosclerosis. Furthermore, cholesterol levels, sterol ester (27:1/18:2) levels, triacylglycerol (52:4) levels, triacylglycerol (52:5) levels, diacylglycerol (18:1_18.2) levels, and triacylglycerol (53:4) levels are positively correlated with the risk of coronary atherosclerosis. These six lipid metabolites have the potential as new predictors of the risk of atherosclerosis, providing new insights into the treatment and prevention of cardiovascular diseases.

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基于脂质组学的冠状动脉粥样硬化发病机制研究：一项孟德尔随机研究。

背景：脂质代谢物与心血管疾病，特别是冠状动脉粥样硬化之间的关系已经引起了相当大的关注。方法：采用双样本磁共振框架研究脂质代谢物与冠状动脉粥样硬化风险之间的关系。研究人员检查了两个GWAS数据集，从51,589例病例和343,079例对照，以及14,334例病例和346,860例对照中获取snp交集，以确定冠状动脉粥样硬化的遗传易感性。随机效应逆方差加权（IVW） MR分析通过一系列敏感性评估来衡量我们研究结果的稳健性，并检测任何违反MR假设的情况。结果：通过IVW、MR-Egger和加权中位数回归方法，我们推断胆固醇水平、甾醇酯（27:1/18:2）水平、甘油三酯（52:4）水平、甘油三酯（52:5）水平、二甘油三酯（18:1_18.2）水平、甘油三酯（53:4）6种脂质代谢物可直接影响动脉粥样硬化的发展。结论：总之，我们的研究全面说明了脂质代谢产物与冠状动脉粥样硬化风险之间的因果关系。此外，胆固醇水平、甾醇酯（27:1/18:2）水平、三酰甘油（52:4）水平、三酰甘油（52:5）水平、二酰甘油（18:1_18.2）水平和三酰甘油（53:4）水平与冠状动脉粥样硬化的风险呈正相关。这六种脂质代谢物有可能作为动脉粥样硬化风险的新预测因子，为心血管疾病的治疗和预防提供新的见解。

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来源期刊

Hereditas Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.80

自引率

3.70%

发文量

期刊介绍： For almost a century, Hereditas has published original cutting-edge research and reviews. As the Official journal of the Mendelian Society of Lund, the journal welcomes research from across all areas of genetics and genomics. Topics of interest include human and medical genetics, animal and plant genetics, microbial genetics, agriculture and bioinformatics.