Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-02-01 DOI:10.1016/j.jpsychires.2025.01.045

Yuxing Jared Yao , Yu Chen , Chiang-Shan R. Li

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引用次数: 0

Abstract

Introduction

The hypothalamus plays a pivotal role in supporting motivated behaviors, including aggression. Previous work suggested differential roles of the medial (MH) and lateral hypothalamus (LH) in aggressive behaviors, but little is known about how their resting-state functional connectivity (rsFC) may relate to aggression in humans.

Methods

We employed the data from the Human Connectome Project (HCP) and examined the rsFC's of LH and MH in 745 young adults (393 women). We also explored sex differences in the rsFC's. We processed the imaging data with published routines and evaluated the results of voxel-wise regression on the aggression score, as obtained from Achenbach Adult Self Report, with a corrected threshold.

Results

The analyses revealed significant rsFC's between the LH and clusters in the middle temporal and occipital gyri across all subjects and in the thalamus for men, both in negative correlation with the aggression score. The slope test confirmed sex difference in the correlation between the LH-thalamus rsFC and aggression score. No significant rsFC was observed for the MH.

Conclusions

These findings suggest a role of the LH rsFC's and sex differences in the LH-thalamus rsFC in the manifestation of aggression in humans. The findings highlight the need for further research into sex-specific neural pathways in aggression and other related behavioral traits of importance to mental health.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;