General movements and neurodevelopmental outcome at 6 years in extremely preterm born children

IF 2.2 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Early human development Pub Date : 2025-02-01 DOI:10.1016/j.earlhumdev.2025.106205

Piia Lönnberg , Marjo Metsäranta , Irmeli Rajantie , Ritva Haajanen , Elina Wolford , Aulikki Lano

{"title":"General movements and neurodevelopmental outcome at 6 years in extremely preterm born children","authors":"Piia Lönnberg , Marjo Metsäranta , Irmeli Rajantie , Ritva Haajanen , Elina Wolford , Aulikki Lano","doi":"10.1016/j.earlhumdev.2025.106205","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Infants born extremely preterm (EPT) face a variety of neurodevelopmental challenges. Those most at risk of adverse outcomes should be detected early.</div></div><div><h3>Aims</h3><div>To assess General Movements (GMs) at fidgety age in EPT infants and to investigate whether fidgety movements (FMs) and Motor Optimality Scores – Revised (MOS-R) are associated with neurodevelopmental outcome at six years.</div></div><div><h3>Study design</h3><div>Longitudinal cohort study.</div></div><div><h3>Subjects</h3><div>Thirty-eight EPT children (< 28 weeks of gestation, 11 girls).</div></div><div><h3>Outcome measures</h3><div>GMs were assessed from video recordings at three months corrected age using the Prechtl General Movements Assessment and The Motor Optimality Score for 3- to 5-Month-Old Infants – Revised. Neurological (Touwen), cognitive (WPPSI-III) and neuropsychological (NEPSY-II, visuospatial and attention) outcomes were evaluated at six years.</div></div><div><h3>Results</h3><div>Nine (24 %) of the infants had aberrant (abnormal/sporadic/absent) FMs and all but one had abnormal movement character. Median MOS-R was 21. Infants with aberrant FMs had significantly higher odds ratio (OR) for full-scale intelligence quotient ≤ 85 (FSIQ, OR 7.7, <em>p</em> = 0.03) and auditory attention ≤ −1SD (OR 12.8, <em>p</em> = 0.04). MOS-R scores correlated positively with FSIQ (Spearman <em>r</em> = 0.39, <em>p</em> = 0.02), performance IQ (<em>r</em> = 0.47, <em>p</em> = 0.004), visuospatial processing (Geometric Puzzles, <em>r</em> = 0.53, <em>p</em> = 0.006) and visual attention (<em>r</em> = 0.29, <em>p</em> = 0.01). Overall outcome or neurological outcome did not reach statistical significance in associations with aberrant FMs or MOS-R.</div></div><div><h3>Conclusion</h3><div>Aberrant FMs and lower MOS-R are associated with worse neurodevelopmental outcomes when compared to normal FMs and/or higher MOS-R.</div></div>","PeriodicalId":11435,"journal":{"name":"Early human development","volume":"201 ","pages":"Article 106205"},"PeriodicalIF":2.2000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Early human development","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0378378225000155","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Infants born extremely preterm (EPT) face a variety of neurodevelopmental challenges. Those most at risk of adverse outcomes should be detected early.

Aims

To assess General Movements (GMs) at fidgety age in EPT infants and to investigate whether fidgety movements (FMs) and Motor Optimality Scores – Revised (MOS-R) are associated with neurodevelopmental outcome at six years.

Study design

Longitudinal cohort study.

Subjects

Thirty-eight EPT children (< 28 weeks of gestation, 11 girls).

Outcome measures

GMs were assessed from video recordings at three months corrected age using the Prechtl General Movements Assessment and The Motor Optimality Score for 3- to 5-Month-Old Infants – Revised. Neurological (Touwen), cognitive (WPPSI-III) and neuropsychological (NEPSY-II, visuospatial and attention) outcomes were evaluated at six years.

Results

Nine (24 %) of the infants had aberrant (abnormal/sporadic/absent) FMs and all but one had abnormal movement character. Median MOS-R was 21. Infants with aberrant FMs had significantly higher odds ratio (OR) for full-scale intelligence quotient ≤ 85 (FSIQ, OR 7.7, p = 0.03) and auditory attention ≤ −1SD (OR 12.8, p = 0.04). MOS-R scores correlated positively with FSIQ (Spearman r = 0.39, p = 0.02), performance IQ (r = 0.47, p = 0.004), visuospatial processing (Geometric Puzzles, r = 0.53, p = 0.006) and visual attention (r = 0.29, p = 0.01). Overall outcome or neurological outcome did not reach statistical significance in associations with aberrant FMs or MOS-R.

Conclusion

Aberrant FMs and lower MOS-R are associated with worse neurodevelopmental outcomes when compared to normal FMs and/or higher MOS-R.

查看原文本刊更多论文

求助全文

约1分钟内获得全文求助全文

来源期刊

Early human development 医学-妇产科学

CiteScore

4.40

自引率

4.00%

发文量

100

审稿时长

46 days

期刊介绍： Established as an authoritative, highly cited voice on early human development, Early Human Development provides a unique opportunity for researchers and clinicians to bridge the communication gap between disciplines. Creating a forum for the productive exchange of ideas concerning early human growth and development, the journal publishes original research and clinical papers with particular emphasis on the continuum between fetal life and the perinatal period; aspects of postnatal growth influenced by early events; and the safeguarding of the quality of human survival. The first comprehensive and interdisciplinary journal in this area of growing importance, Early Human Development offers pertinent contributions to the following subject areas: Fetology; perinatology; pediatrics; growth and development; obstetrics; reproduction and fertility; epidemiology; behavioural sciences; nutrition and metabolism; teratology; neurology; brain biology; developmental psychology and screening.