Development of the symptomatic dermographism quality of life questionnaire

IF 4.6 2区医学 Q2 ALLERGY

Clinical and Translational Allergy Pub Date : 2025-01-31 DOI:10.1002/clt2.70038

Melba Muñoz, Nicole Schoepke, Sabine Altrichter, Petra Staubach, Clara Geppert-Steidl, Leslie Durner, Jonathan A. Bernstein, Marcus Maurer, Karsten Weller

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引用次数: 0

Abstract

Background

Symptomatic Dermographism (SD), also known as “urticaria factitia”, is the most common subtype of chronic inducible urticaria. Affected patients develop itch and strip-shaped wheals that usually last for 30 min after minor stroking, rubbing, or scratching of the skin. The quality of life (QoL) of patients with SD is often strongly affected. However, a QoL instrument to properly assess this impairment is not yet available.

Objective

The aim of this study was to develop the first disease-specific patient reported outcome measure|patient reported outcome measures (PROM) to evaluate QoL impairment in SD patients, the Symptomatic Dermographism Quality of Life Questionnaire (SD-QoL).

Methods

SD-QoL was developed following current guidelines for PROM development. We first generated a hypothetical conceptional framework of the SD-QoL, followed by an item generation and an item selection/reduction phase.

Results

During the item generation phase, 69 potential items of the SD-QoL were generated by applying a combined approach consisting of literature review, expert input as well as semi-structured interviews with affected patients. During the item selection phase, we reduced this long list of items to a final 13-item set by means of impact analysis, inter-item correlation, and additional criteria for item reduction, including an expert review for content (face) validity. Finally, a US-American-English version of the SD-QoL was developed using a structured translation process.

Conclusions and Clinical Relevance

The SD-QoL is the first disease-specific-QoL instrument for SD with a recall period of 7 days that allows the assessment of QoL in SD patients. A subsequent validation study will determine its validity and reliability.

Abstract Image

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症状性人口统计学生活质量问卷的编制。

背景：症状性皮肤炎（SD），也被称为“性荨麻疹”，是慢性诱导性荨麻疹最常见的亚型。受影响的患者在轻微的抚摸、摩擦或抓挠皮肤后会出现瘙痒和条状的皮疹，通常持续30分钟。SD患者的生活质量（QoL）往往受到严重影响。然而，目前还没有一种能够正确评估这种损害的生活质量工具。目的：本研究的目的是开发首个疾病特异性患者报告结果测量指标|患者报告结果测量（PROM）来评估SD患者的生活质量损害，即症状性皮肤特征生活质量问卷（SD-QoL）。方法：SD-QoL是根据目前的PROM开发指南制定的。我们首先生成了SD-QoL的假设概念框架，然后是项目生成和项目选择/减少阶段。结果：在项目生成阶段，采用文献综述、专家输入和半结构化患者访谈相结合的方法，生成了69个SD-QoL的潜在项目。在项目选择阶段，我们通过影响分析、项目间相关性和项目减少的附加标准（包括内容（面）效度的专家审查），将这个长长的项目列表减少到最终的13个项目集。最后，使用结构化翻译过程开发了SD-QoL的美国-美国-英语版本。结论及临床意义：SD-QoL是首个SD疾病特异性QoL仪器，回忆期为7天，可用于评估SD患者的生活质量。后续的验证研究将确定其效度和信度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical and Translational Allergy Immunology and Microbiology-Immunology

CiteScore

7.50

自引率

4.50%

发文量

117

审稿时长

12 weeks

期刊介绍： Clinical and Translational Allergy, one of several journals in the portfolio of the European Academy of Allergy and Clinical Immunology, provides a platform for the dissemination of allergy research and reviews, as well as EAACI position papers, task force reports and guidelines, amongst an international scientific audience. Clinical and Translational Allergy accepts clinical and translational research in the following areas and other related topics: asthma, rhinitis, rhinosinusitis, drug hypersensitivity, allergic conjunctivitis, allergic skin diseases, atopic eczema, urticaria, angioedema, venom hypersensitivity, anaphylaxis, food allergy, immunotherapy, immune modulators and biologics, animal models of allergic disease, immune mechanisms, or any other topic related to allergic disease.