A Universal Method for the Synthesis of new Heterocyclic Systems: Pyrimido[2,1-f][1,2,4]triazines.

IF 2.5 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemistryOpen Pub Date : 2025-01-31 DOI:10.1002/open.202400379

Samvel N Sirakanyan, Domenico Spinelli, Athina Geronikaki, Victor G Kartsev, Elmira K Hakobyan, Hasmik V Jughetsyan, Hasmik A Yegoryan, Anush A Hovakimyan

引用次数: 0

Abstract

The synthesis of pyrimido[2,1-f][1,2,4]triazines was performed in four steps. Compounds obtained by acylation of the starting amino esters of thieno[2,3-b]pyridines were reacted with various amines. The resulting amino derivatives underwent cyclization in the presence of hydrazine hydrate leading to new aminomethyl derivatives of thieno[3,2-d]pyrimidines. Further cyclization of the latter resulted to the synthesis of new unique heterocyclic systems: pyrido[3'',2'':4',5']thieno[3',2':4,5]pyrimido[2,1-f][1,2,4]triazines. The uniqueness of these systems lies in the fact that even the combination of the last two cycles represents a new heterocyclic system.

查看原文本刊更多论文

合成新杂环体系：嘧啶[2,1-f][1,2,4]三嗪的通用方法。

采用四步法合成了嘧啶[2,1-f][1,2,4]三嗪类化合物。由噻吩[2,3-b]吡啶起始氨基酯酰化得到的化合物与各种胺反应。得到的氨基衍生物在水合肼存在下进行环化，生成新的噻吩[3,2-d]嘧啶的氨基甲基衍生物。后者进一步环化，合成了新的独特的杂环体系：吡啶[3',2':4 ',5']，噻吩[3',2':4,5]，嘧啶[2,1-f][1,2,4]三嗪。这些系统的独特之处在于，即使最后两个环的组合也代表了一个新的杂环系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

期刊介绍： ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.