Stable vitiligo treated by transplantation of autologous melanocytes: a meta-analysis

IF 1.8 4区医学 Q3 DERMATOLOGY

Archives of Dermatological Research Pub Date : 2025-02-01 DOI:10.1007/s00403-025-03846-3

Xue Cao, Wentao Zhang, Zhongyuan Jia, Shaohong Ma, Lixia Liu

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引用次数: 0

Abstract

Objective

To systematically evaluate the efficacy of culture and nonculture autologous melanocyte transplantation and other methods for stable vitiligo.

Methods

PubMed, Embase, WebofScience, TheCochraneLibrary, Chinese Journal Full-text Database (CNKI), VIP Chinese Scientific Journal Full-text Database (VIP), Wanfang database, were included in the clinical study of autologous cell transplantation for the treatment of stable vitiligo. For the meta-analysis of the corresponding studies with Revman5.3 software.

Results

17 high-quality studies were included in this meta-analysis, totaling 1199 patients, Meta-analysis showed that there was no significant difference in the efficacy of autologous cultured melanocytes transplantation (CMT) and melanocytes + keratinocytes, CMT and autologous nonculture suspension transplantation (NCES) in stable vitiligo (P > 0.05); There was a significant difference between CMT and CMT + phototherapy in stable vitiligo (P < 0.00001); There was no significant difference in the efficacy of NCES and NCES + other components, NCES and NCES + other therapies, and NCES and NCES + phototherapy for stable vitiligo (P > 0.05); There was a significant difference in the efficacy of cell transplantation and cell transplantation and cell transplantation + other therapy, cell transplantation and cell transplantation + phototherapy,cell transplantation and cell transplantation + narrow spectrum ultraviolet (NBUVB) in stable vitiligo (P < 0.00001).

Conclusion

Both NCES and CMT transplantation treated stable vitiligo and had no direct relationship with the components contained in the suspension. Melanocyte transplantation and melanocyte transplantation combined with other treatment methods is better than single melanocyte transplantation for vitiligo. Due to the number and quality of included studies, the above conclusions need to be confirmed by more reasonably designed randomized controlled clinical studies.

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来源期刊

Archives of Dermatological Research 医学-皮肤病学

CiteScore

4.10

自引率

3.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Archives of Dermatological Research is a highly rated international journal that publishes original contributions in the field of experimental dermatology, including papers on biochemistry, morphology and immunology of the skin. The journal is among the few not related to dermatological associations or belonging to respective societies which guarantees complete independence. This English-language journal also offers a platform for review articles in areas of interest for dermatologists and for publication of innovative clinical trials.