Gravimetric drop-on-demand inkjet deposition for imaging phantoms with traceable activity

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-01-18 DOI:10.1016/j.apradiso.2025.111683

Sean P. Jollota , Denis E. Bergeron , R. Michael Verkouteren , Svetlana Nour , Ryan P. Fitzgerald , Ohyun Kwon , Jeffrey L. Radtke , Bryan P. Bednarz , Brian W. Miller , Larry A. DeWerd

引用次数: 0

Abstract

Autoradiography is an important tool in preclinical investigations with alpha-emitting radionuclides. Precise biodistribution studies establish the effectiveness of biological “targeting” strategies, assuring that the promise of targeted alpha therapy (TAT) is realized. There is a need for calibration and test objects (phantoms) to evaluate and support precise autoradiography. Leveraging recent advances in drop-on-demand inkjet methods, we demonstrate the preparation of an autoradiography phantom with activity traceable to primary measurements. With digital autoradiography we demonstrate spatial resolution less than 20 μm. Corrections required to calibrate a digital autoradiography system for activity are discussed.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.