Seroepidemiology (2018–2024) and epidemic spread of an emerging human parvovirus B19 genotype 1 (subtype 1a2) variant in Hungary, 2023/2024

IF 2.5 4区医学 Q3 VIROLOGY

Archives of Virology Pub Date : 2025-02-02 DOI:10.1007/s00705-025-06228-2

Fruzsina Tóth, Tímea Moser, Ákos Boros, Benigna Balázs, Károly Takáts, Péter Pankovics, Gábor Reuter

引用次数: 0

Abstract

An unusually large number of human parvovirus B19 (B19V) infections were reported in European countries in 2023/2024, but the genetic background of this B19V epidemic strain is unknown. In this study, there was a larger number of confirmed B19V infections (five in 2021, eight in 2023, and 59 in 2024) and higher IgG seroprevalence (41.4% in 2022 and 54.3% in 2024) in Transdanubia, Hungary, in 2024 compared to 2018-2023. A B19V genotype 1a2 variant (prototype, 1338/HUN/2024, PQ155933) with common and unique nucleotide insertions in the untranslated regions of the genome and nonsynonymous and synonymous mutations in the coding region (NS1 and VP1) could be responsible to the ongoing B19V epidemic in Europe.

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2023/2024年匈牙利新发人类细小病毒B19基因1型（亚型1a2）变异的血清流行病学（2018-2024年）和流行传播

2023/2024年，欧洲国家报告了异常大量的人细小病毒B19 （B19V）感染，但这种B19V流行毒株的遗传背景尚不清楚。在本研究中，与2018-2023年相比，匈牙利外多瑙河地区2024年确诊的B19V感染人数更多（2021年5人，2023年8人，2024年59人），IgG血清阳性率更高（2022年41.4%，2024年54.3%）。B19V基因型1a2变体（原型，1338/HUN/2024, PQ155933）在基因组的非翻译区具有共同和独特的核苷酸插入，在编码区（NS1和VP1）具有非同义和同义突变，可能是导致欧洲持续流行的B19V的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.