Advances in primary eye care and ophthalmic imaging contribute to earlier detection of uveal melanoma.

IF 3 3区 医学 Q1 OPHTHALMOLOGY
Vilde Bjertnæs, Anna Dalseng Hatling, Olav H Haugen, Jørgen Krohn
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引用次数: 0

Abstract

Purpose: To report how the evolving role of optometrists in primary eye care and advances in ophthalmic imaging have affected diagnosis and management of posterior uveal melanoma (UM).

Methods: Retrospective, single-centre cohort study of patients diagnosed with UM from 1993 to 2022 in Bergen, Norway.

Results: Four hundred nine patients were included, and comparisons were made between those diagnosed from 1993 to 2007 and from 2008 to 2022. The median tumour diameter decreased from 13.3 to 11.3 mm (p = 0.002), and the median tumour thickness decreased from 6.9 to 4.5 mm (p < 0.001). The median distance from the tumour border to the optic disc and to the foveola increased from 3.5 to 4.5 mm (p = 0.011), and from 3.0 to 4.0 mm (p < 0.001), respectively. Two hundred sixty-two patients (64%) experienced symptoms associated with UM, with a median duration of 152.5 and 81 days in the first and second half of the study period, respectively (p < 0.001). The median best corrected visual acuity at diagnosis improved from 0.5 logMAR (Snellen equivalent, 6/19) in the first half to 0.2 logMAR (Snellen equivalent, 6/9.5) in the second half of the period (p < 0.001). The proportion of asymptomatic patients was 23.5% in the first and 41.9% in the second half of the period (p < 0.001). The proportion of UMs incidentally detected by optometrists increased from 3.0% to 18.1% (p = 0.009), and the proportion of UMs incidentally detected by fundus photography increased from 1.5% to 18.1% (p < 0.001).

Conclusions: The temporal changes in patient and tumour characteristics suggest that UMs are now being diagnosed at an earlier stage. This may in part be attributed to the introduction of widefield fundus cameras and increased opportunistic screening of asymptomatic patients.

初级眼科保健和眼科成像的进步有助于早期发现葡萄膜黑色素瘤。
目的:报告验光师在初级眼科保健中的作用的演变和眼科影像学的进展如何影响葡萄膜后黑色素瘤(UM)的诊断和治疗。方法:回顾性、单中心队列研究1993年至2022年在挪威卑尔根诊断为UM的患者。结果:纳入499例患者,将1993 - 2007年诊断的患者与2008 - 2022年诊断的患者进行比较。肿瘤中位直径从13.3 mm减少到11.3 mm (p = 0.002),肿瘤中位厚度从6.9 mm减少到4.5 mm (p)。结论:患者和肿瘤特征的时间变化提示UMs现在被早期诊断。这可能部分归因于广角眼底相机的引入和对无症状患者的机会性筛查的增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Ophthalmologica
Acta Ophthalmologica 医学-眼科学
CiteScore
7.60
自引率
5.90%
发文量
433
审稿时长
6 months
期刊介绍: Acta Ophthalmologica is published on behalf of the Acta Ophthalmologica Scandinavica Foundation and is the official scientific publication of the following societies: The Danish Ophthalmological Society, The Finnish Ophthalmological Society, The Icelandic Ophthalmological Society, The Norwegian Ophthalmological Society and The Swedish Ophthalmological Society, and also the European Association for Vision and Eye Research (EVER). Acta Ophthalmologica publishes clinical and experimental original articles, reviews, editorials, educational photo essays (Diagnosis and Therapy in Ophthalmology), case reports and case series, letters to the editor and doctoral theses.
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