Fluoroquinolone consumption and resistance after an Antibiotic Stewardship Team intervention—An interventional study in a single hospital in Southern Poland from 2018 to 2023

IF 3.8 3区医学 Q2 INFECTIOUS DISEASES

American journal of infection control Pub Date : 2025-01-30 DOI:10.1016/j.ajic.2025.01.017

P. Serwacki MD , D.A. Hareza MD , M. Gajda MD, PhD , W. Świątek-Kwapniewska MSc , M. Adamowska MSc , K. Serwacka MD , G. Zawada MD , M. Wałaszek Assoc. Prof. , J. Wójkowska-Mach Prof.

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引用次数: 0

Abstract

Background

Fluoroquinolones (FQs) are widely used in empiric treatment with progressively rising resistance. Using in-hospital surveillance and following the recommendations of the US Food and Drug Administration and European Medicines Agency, our Antibiotic Stewardship Team(AST) decided to pursue a restrictive policy for FQ utilization. The aim of this study was to evaluate AST intervention restricting FQ use with preauthorization to determine its effectiveness in decreasing consumption and resistance.

Methods

This study was conducted in a 650-bed hospital in Poland during 2018 to 2019 and 2022 (preintervention) and 2023 (postintervention). Antibiotic consumption (ABC) and antibiotic resistance were compared for both periods. ABC was expressed as a defined daily doses (DDD) per 1,000 pds, and antibiotic resistance was expressed as a resistance rate parameter to FQ in select gram-negative bacilli.

Results

The ABC of all antibiotics varied significantly from 2,987.7 DDD/1,000 pds to 3,741.1 DDD/1,000 pds (2018 vs. 2023). The urology ward showed decreasing FQ consumption from 358.9 DDD/1,000 pds to 43.4 DDD/1,000 pds (from 2018 to 2023, P < .001). A 25% reduction in the resistance rate to FQ was observed, with the greatest difference between 2022 (69.9%) and 2023 (52.6%).

Conclusions

This study demonstrates the effectiveness of FQ restriction and preauthorization in a hospital.

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来源期刊

American journal of infection control 医学-传染病学

CiteScore

7.40

自引率

4.10%

发文量

479

审稿时长

24 days

期刊介绍： AJIC covers key topics and issues in infection control and epidemiology. Infection control professionals, including physicians, nurses, and epidemiologists, rely on AJIC for peer-reviewed articles covering clinical topics as well as original research. As the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC)