Efficient enrichment and sensitive determination of endocrine disruptors in PPCPs by novel magnetic covalent organic framework extraction coupled with HPLC-MS/MS

IF 5.6 1区化学 Q1 CHEMISTRY, ANALYTICAL

Talanta Pub Date : 2025-01-28 DOI:10.1016/j.talanta.2025.127667

Zheng Hu , Yuhang Yang , Zhe Li , Qiuying Tao , Yinghong Huang , Xian Wang

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引用次数: 0

Abstract

Endocrine-disrupting chemicals (EDCs) are a growing class of pollutants commonly found in environmental matrices due to their extensive use in pharmaceuticals and personal care products (PPCPs). In this study, a novel magnetic covalent organic framework (COF), Fe₃O₄–COOH@TFP-BHBD, was successfully synthesized and utilized as an adsorbent for magnetic solid-phase extraction (MSPE) of EDCs from PPCPs. The core-shell structured adsorbent demonstrated a high specific surface area, strong magnetic responsiveness and excellent stability. A COF-MSPE-high-performance liquid chromatography-tandem mass spectrometry (COF-MSPE-HPLC-MS/MS) method was developed for the quantitative analysis of EDCs in PPCPs. Under the optimized condition, the detection and quantification limits of this method reached as low as 0.001–0.007 ng/mL and 0.004–0.025 ng/mL, respectively. This method was validated and proven capable to analyze real PPCP samples, while the spiked recovery rates in ranged from 85.62 to 107.83 % with RSD of 2.28–8.58 %. Moreover, the adsorption mechanism was investigated using density functional theory (DFT) calculations. The DFT results revealed that the efficient enrichment capacity of Fe₃O₄–COOH@TFP-BHBD for EDCs can be attributed to π-π interactions and hydrogen bondings. This proposed method provides excellent adsorption ability and sensitivity for the extraction and precise detection of EDCs in PPCPs.

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干扰内分泌的化学物质（EDCs）是环境基质中常见的一类日益增多的污染物，因为它们被广泛应用于药品和个人护理产品（PPCPs）中。本研究成功合成了一种新型磁性共价有机框架（COF）--Fe3O4-COOH@TFP-BHBD，并将其用作磁性固相萃取（MSPE）吸附 PPCPs 中的 EDCs。该核壳结构吸附剂具有高比表面积、强磁响应性和优异的稳定性。建立了COF-MSPE-高效液相色谱-串联质谱（COF-MSPE-HPLC-MS/MS）方法，用于定量分析PPCPs中的EDCs。在优化条件下，该方法的检出限和定量限分别低至0.001-0.007 ng/mL和0.004-0.025 ng/mL。该方法的加标回收率为85.62%～107.83%，RSD为2.28%～8.58%。此外，还利用密度泛函理论（DFT）计算研究了吸附机理。DFT 结果表明，Fe3O4-COOH@TFP-BHBD 对 EDCs 的高效富集能力可归因于 π-π 相互作用和氢键。该方法具有优异的吸附能力和灵敏度，可用于提取和精确检测 PPCPs 中的 EDCs。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Talanta 化学-分析化学

CiteScore

12.30

自引率

4.90%

发文量

861

审稿时长

29 days

期刊介绍： Talanta provides a forum for the publication of original research papers, short communications, and critical reviews in all branches of pure and applied analytical chemistry. Papers are evaluated based on established guidelines, including the fundamental nature of the study, scientific novelty, substantial improvement or advantage over existing technology or methods, and demonstrated analytical applicability. Original research papers on fundamental studies, and on novel sensor and instrumentation developments, are encouraged. Novel or improved applications in areas such as clinical and biological chemistry, environmental analysis, geochemistry, materials science and engineering, and analytical platforms for omics development are welcome. Analytical performance of methods should be determined, including interference and matrix effects, and methods should be validated by comparison with a standard method, or analysis of a certified reference material. Simple spiking recoveries may not be sufficient. The developed method should especially comprise information on selectivity, sensitivity, detection limits, accuracy, and reliability. However, applying official validation or robustness studies to a routine method or technique does not necessarily constitute novelty. Proper statistical treatment of the data should be provided. Relevant literature should be cited, including related publications by the authors, and authors should discuss how their proposed methodology compares with previously reported methods.