Effect of Saccharomyces cerevisiae β-glucan on the T helper cytokine profile

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-01-30 DOI:10.1016/j.cyto.2025.156871

Patricia Vuscan , Rutger J. Röring , Brenda Kischkel , Maria Tintoré , Jordi Cuñé , Carlos de Lecea , Leo A.B. Joosten , Mihai G. Netea

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引用次数: 0

Abstract

ABBi16 is a high-complexity blend of β-1,3/1,6-glucans from Saccharomyces cerevisiae with strong immunomodulatory activities, that have been recently shown to support anti-tumoral immune responses through the induction of trained immunity. Whether ABBi16 also modulates the balance between the various T helper (Th) lymphocyte responses is not known. Here, we show that ABBi16 induces Th1 responses, as indicated by stimulation of IFNγ and TNF production by human peripheral blood mononuclear cells (PBMCs). Moreover, the elevated secretion of IL-10 and IL-22 suggests a potential regulatory response of the Th1/Th2/Th17 balance. Co-stimulating PBMCs with ABBi16 alongside Bacille Calmette-Guerin (BCG), IL-1beta + IL-23, and IL-12 + IL-18 cytokine combinations further enhanced Th1 polarization and IL-22 induction, hinting at an additive effect of β-glucan on both Th1 and regulatory Th17 immune responses. ABBi16 did not induce IL-17 production, the prototype pro-inflammatory product of Th17 responses, suggesting that it can be safely used as an oral supplement in patients with autoimmune conditions. These results highlight the potential of ABBi16 to regulate the Th1/Th2/Th17 balance toward antimicrobial and regulatory effects.

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酿酒酵母β-葡聚糖对辅助性T细胞因子谱的影响。

ABBi16是来自酿酒酵母的β-1,3/1,6-葡聚糖的高复杂性混合物，具有很强的免疫调节活性，最近已被证明通过诱导训练免疫来支持抗肿瘤免疫反应。ABBi16是否也调节各种T辅助（Th）淋巴细胞反应之间的平衡尚不清楚。在这里，我们发现ABBi16诱导Th1反应，正如人外周血单个核细胞（PBMCs）刺激IFNγ和TNF产生所表明的那样。此外，IL-10和IL-22的分泌升高提示Th1/Th2/Th17平衡的潜在调节反应。ABBi16与卡介苗、il -1 β + IL-23和IL-12 + IL-18细胞因子联合共刺激pbmc，进一步增强了Th1极化和IL-22诱导，提示β-葡聚糖对Th1和调节性Th17免疫应答均有加性作用。ABBi16不诱导IL-17的产生，IL-17是Th17反应的原型促炎产物，这表明它可以安全地用作自身免疫性疾病患者的口服补充剂。这些结果强调了ABBi16调节Th1/Th2/Th17平衡的潜力，从而达到抗菌和调节作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.