{"title":"Perioperative chemotherapy superior to preoperative chemoradiotherapy for locally advanced EAC","authors":"David Killock","doi":"10.1038/s41571-025-00995-2","DOIUrl":null,"url":null,"abstract":"<p>Two multimodal treatment strategies, perioperative chemotherapy and preoperative chemoradiotherapy, have been shown to improve overall survival (OS) compared to surgery alone in patients with locally advanced oesophageal adenocarcinoma (EAC); however, the optimal approach has been unclear. Newly published results from the phase III ESOPEC trial demonstrate the superiority of the perioperative strategy.</p><p>In ESOPEC, 438 patients with resectable cT1–4aN+ or cT2–4aN0 EAC were randomly assigned (1:1) to receive four preoperative and four postoperative cycles of fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT) or preoperative radiotherapy (41.4 Gy in 23 fractions) plus concurrent weekly carboplatin and paclitaxel. OS was the primary end point.</p>","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"7 1","pages":""},"PeriodicalIF":81.1000,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Clinical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41571-025-00995-2","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Two multimodal treatment strategies, perioperative chemotherapy and preoperative chemoradiotherapy, have been shown to improve overall survival (OS) compared to surgery alone in patients with locally advanced oesophageal adenocarcinoma (EAC); however, the optimal approach has been unclear. Newly published results from the phase III ESOPEC trial demonstrate the superiority of the perioperative strategy.
In ESOPEC, 438 patients with resectable cT1–4aN+ or cT2–4aN0 EAC were randomly assigned (1:1) to receive four preoperative and four postoperative cycles of fluorouracil, leucovorin, oxaliplatin and docetaxel (FLOT) or preoperative radiotherapy (41.4 Gy in 23 fractions) plus concurrent weekly carboplatin and paclitaxel. OS was the primary end point.
期刊介绍：
Nature Reviews publishes clinical content authored by internationally renowned clinical academics and researchers, catering to readers in the medical sciences at postgraduate levels and beyond. Although targeted at practicing doctors, researchers, and academics within specific specialties, the aim is to ensure accessibility for readers across various medical disciplines. The journal features in-depth Reviews offering authoritative and current information, contextualizing topics within the history and development of a field. Perspectives, News & Views articles, and the Research Highlights section provide topical discussions, opinions, and filtered primary research from diverse medical journals.
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