The Biological Activities of Ent-Polyalthic Acid.

IF 2.3 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry & Biodiversity Pub Date : 2025-01-31 DOI:10.1002/cbdv.202402894

Cassia S Mizuno, Raquel Alves Dos Santos, Natalia Nascimento Silveira

引用次数: 0

Abstract

Copaiba oleoresin is one of the most popular medicines in the Amazon. Ent-polyalthic acid (PA) is one of the diterpenes found in the oleoresin and has been shown to have several biological activities including antimicrobial, antifungal, antiparasitic, and many others. Therefore, it could be used as a lead compound in the development of new drugs. This review describes in vitro and in vivo biological activities, and the mechanisms of action of PA reported in the literature. Although there are several studies, the majority reported the results of in vitro studies. Effects in humans are nonexistent since PA has not been tested in any clinical trials.

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来源期刊

Chemistry & Biodiversity 环境科学-化学综合

CiteScore

3.40

自引率

10.30%

发文量

475

审稿时长

2.6 months

期刊介绍： Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.