Samuel W Failor, Matteo Carandini, Kenneth D Harris
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Abstract
Sensory and behavioral experience can alter visual cortical stimulus coding, but the precise form of this plasticity is unclear. We measured orientation tuning in 4,000-neuron populations of mouse V1 before and after training on a visuomotor task. Changes to single-cell tuning curves appeared complex, including development of asymmetries and of multiple peaks. Nevertheless, these complex tuning curve transformations can be explained by a simple equation: a convex transformation suppressing responses to task stimuli specifically in cells responding at intermediate levels. The strength of the transformation varies across trials, suggesting a dynamic circuit mechanism rather than static synaptic plasticity. The transformation results in sparsening and orthogonalization of population codes for task stimuli. It cannot improve the performance of an optimal stimulus decoder, which is already perfect even for naive codes, but it improves the performance of a suboptimal decoder model with inductive bias as might be found in downstream readout circuits.
期刊介绍：
Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted.
The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership.
The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.
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